1-(2,4-DIFLUOROPHENYL)-1H-IMIDAZOLE synthesis
- Product Name:1-(2,4-DIFLUOROPHENYL)-1H-IMIDAZOLE
- CAS Number:1114295-72-5
- Molecular formula:C9H6F2N2
- Molecular Weight:180.15
50-00-0
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Yield:1114295-72-5 70%
Reaction Conditions:
Stage #1: Glyoxal;2,4-difluorophenylamine in methanol at 20; for 16 h;
Stage #2: formaldehydwith ammonium chloride in methanol at 65; for 1 h;
Stage #3: with phosphoric acid in methanol; for 48 h;Reflux;
References:
Lerch, Swantje;Strassner, Thomas [Chemistry - A European Journal,2021,vol. 27,# 62,p. 15554 - 15557] Location in patent:supporting information