1-(2,5-Dimethoxyphenyl)-2-nitroethanol synthesis

Yield:14438-63-2 96%

Reaction Conditions:

with sodium hydroxide in ethanol;water at 10 - 15; for 0.5 h;Temperature;Solvent;Reagent/catalyst;

Steps:

1.1 Preparation of 1-(2,5-dimethoxyphenyl)-2-nitroethanol

In an electric stirrer and thermometer2L four-necked flask was added 294.0 g nitromethane (4.8 mol)200.0 g (1.2mo 1) 2,5-dimethoxybenzaldehyde and 480 ml of ethanol, the temperature of the reaction solution was reduced to 10 to 15 ° C,Then, 126 ml (1.32 mil) of 10.5 M aqueous sodium hydroxide solution was added dropwise and the mixture was stirred for 30 minutes after the dropwise addition.After the addition of 660 ml (1.62 mol) of 2.45 M acetic acid in water was neutralized and the reaction was continued for 30 minutes. The filter cake was rinsed twice with a small amount of petroleum ether and dried to give 261.7 g of 1- (2,5-dimethyl Oxyphenyl) -2-nitroethanol, HPLC purity 98.9% yieldFor 96%

References:

CN105622434,2016,A Location in patent:Paragraph 0032-0034