1-(2-Methyl-3-nitrophenyl)ethanone synthesis
- Product Name:1-(2-Methyl-3-nitrophenyl)ethanone
- CAS Number:75473-11-9
- Molecular formula:C9H9NO3
- Molecular Weight:179.17
136774-69-1
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75473-11-9
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$329.00/100mg
Yield:75473-11-9 67%
Reaction Conditions:
in water;trifluoroacetic acid;
Steps:
2 1-(2-Methyl-3-nitrophenyl)ethanone
EXAMPLE 2 1-(2-Methyl-3-nitrophenyl)ethanone A solution of ethyl 2-methyl-3-nitro-β-oxobenzenepropanoate (10.0 g, 39.7 mmol) in 100 mL of 30% water/trifluoroacetic acid is heated at reflux for 5 hours. The reaction mixture is cooled to room temperature, diluted with water (100 mL), and extracted with ether. The organic layer is washed with water, saturated aqueous sodium bicarbonate, and brine. Evaporation of the organic layer, followed by recrystallization of the residue gives 1-(2-methyl-3-nitrophenyl)ethanone (4.8 g, 67%), mp=49-51° C.
References:
US5017604,1991,A
55289-35-5
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97674-02-7
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75473-11-9
26 suppliers
$329.00/100mg
120100-32-5
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75473-11-9
26 suppliers
$329.00/100mg
39053-41-3
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75473-11-9
26 suppliers
$329.00/100mg