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4394-54-1

1-(3-chloro-4-methoxyphenyl)propan-1-one synthesis

8synthesis methods
Preparation by acylation of 2-chloroanisole,
with propionic anhydride in the presence of ferric chloride (62%);
with propionyl chloride in the presence of aluminium chloride in carbon disulfide (62%), in methylene chloride for 3 h at 0° or for 1.5 h at r.t. with addition of ammonium chloride (72%).
-

Yield:4394-54-1 82%

Reaction Conditions:

with dipyridinium dichromate in dichloromethane at 25;

References:

Swarts, Henk J.;Verhagen, Frank J. M.;Field, Jim A.;Wijnberg, Joannes B. P. A. [Journal of Natural Products,1998,vol. 61,# 9,p. 1110 - 1114]