1-(3-HYDROXYPROPYL)-1H-IMIDAZOLE synthesis
- Product Name:1-(3-HYDROXYPROPYL)-1H-IMIDAZOLE
- CAS Number:51390-23-9
- Molecular formula:C6H10N2O
- Molecular Weight:126.16
288-32-4
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Yield: 51%
Reaction Conditions:
in toluene for 5 h;Reflux;
Steps:
3-(1H-Imidazol-1-yl)propan-1-ol (1b).
A mixtureof 2.55 g (0.0375 mol) of imidazole, 3.83 g(0.0375 mol) of trimethylene carbonate, and 6 mL oftoluene was refluxed for 5 h. After cooling, the bottomlayer was separated and distilled under reduced pressure.Yield 2.41 g (51%), bp 190-193°C (5 mm Hg).1H NMR spectrum, δ, ppm: 1.83 q (2H, CH2, J =6.5 Hz), 3.36 t (2H, CH2O, J = 6.1 Hz), 4.01 t (2H,CH2N, J = 7.1 Hz), 4.71 br.s (1H, OH), 6.88 t (1H,4-H, J = 1.3 Hz), 7.15 t (1H, 5-H, J = 1.3 Hz), 7.60 br.s(1H, 2-H). Found, %: C 57.18; H 8.03; N 22.18.C6H10N2O. Calculated, %: C 57.12; H 7.99; N 22.21.
References:
Gabov;Khamidullina;Puzyrev;Ezhikova;Kodess;Pestov [Russian Journal of Organic Chemistry,2020,vol. 56,# 12,p. 2079 - 2086][Zh. Org. Khim.,2020,p. 2079 - 2086,8]
18999-46-7
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51390-23-9
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24215-02-9
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288-32-4
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627-30-5
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51390-23-9
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$45.00/25mg
288-32-4
1042 suppliers
$5.00/25g
627-18-9
391 suppliers
$9.00/1g
51390-23-9
45 suppliers
$45.00/25mg