Welcome to chemicalbook!
Chinese English Japanese Germany Korea
400-158-6606
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List 1-(3-Methoxypropyl)-4-piperidinamine

1-(3-Methoxypropyl)-4-piperidinamine synthesis

7synthesis methods
N-(1-(3-methoxypropyl)piperidin-4-yl)acetamide (10.72g, 0.05mol) was added to HCl-methanol solution (0.5M, 180ml), and the temperature was controlled at 2025°C After the reaction was detected, it was filtered, and the filter cake was washed with dichloromethane and dried to obtain 1-(3-Methoxypropyl)-4-piperidinamine with a yield of 96.4% and a purity of 99.7%.
-

Yield:179474-79-4 83%

Reaction Conditions:

with 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione;potassium hydroxide in water;acetonitrile at 5 - 25; for 13 h;

Steps:

7 Example 7 Synthesis of 1- (3-methoxypropyl) -4-piperidinamine (I)

A solution of 4-formamide-1- (3-methoxypropyl) -piperidine (III) (229 g, 1.14 mol), water (2.06 L) and acetonitrile (571.9 g)After adding KOH (287.3 g, 5.13 mol), the reaction was carried out at a temperature of not higher than 5 ° C by adding dibromohydantoin (180.2 g, 0.63 mol) and the temperature was raised to 15-25 ° C for 13 hours to stop the reaction.The reaction solution was concentrated under reduced pressure at 55 ° C to recover acetonitrile.The residue was extracted with DCM and the organic layer was dried over anhydrous sodium sulfate,And the organic phase was concentrated under reduced pressure at 50 ° C to give 178.2 g of a pale yellow liquid,The yield was 95% (in terms of II-1) and the GC purity was 98.6%.The product was placed in a distillation flask, the pump was decompressed (with a thorned distillation column)External temperature gradient temperature (5 / times),When the internal temperature rose to 72 ~ 73 ,The fractions were collected to give 148 g of colorless transparent liquid,The distillation yield was 83%

References:

CN106146386,2016,A Location in patent:Paragraph 0064; 0065; 0066; 0067