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4-Hydroxypiperidine

CAS No.
5382-16-1
Chemical Name:
4-Hydroxypiperidine
Synonyms
PIPERIDIN-4-OL;4-PIPERIDINOL;4PPOL;4-piperidinyl;AURORA KA-1006;Piperidine-4α-ol;Piperidine-4β-ol;4-Hydropiperidine;4-Piperidinol ,99%;4-hydroxypiperdine
CBNumber:
CB0157139
Molecular Formula:
C5H11NO
Molecular Weight:
101.15
MDL Number:
MFCD00005999
MOL File:
5382-16-1.mol
MSDS File:
SDS
Last updated:2023-04-23 13:52:06

4-Hydroxypiperidine Properties

Melting point 86-90 °C
Boiling point 108-114 °C/10 mmHg (lit.)
Density 0.9903 (rough estimate)
vapor pressure 13Pa at 25℃
refractive index 1.4400 (estimate)
Flash point 226 °F
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility Chloroform (Slightly), Methanol (Slightly)
form Solid
pka 14.94±0.20(Predicted)
color Off-White to pale Yellow
PH 11.5-11.7 (H2O)Aqueous solution
Water Solubility soluble
Sensitive Hygroscopic
BRN 102738
InChIKey HDOWRFHMPULYOA-UHFFFAOYSA-N
LogP -0.35 at 25℃
CAS DataBase Reference 5382-16-1(CAS DataBase Reference)
FDA UNII KC61EA060X
NIST Chemistry Reference 4-Hydroxypiperidine(5382-16-1)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313
Hazard Codes  Xi,C
Risk Statements  36/37/38-34
Safety Statements  26-36-37/39-45-36/37/39-27
RIDADR  3263
WGK Germany  3
Hazard Note  Irritant
HazardClass  8
PackingGroup  III
HS Code  29333999
NFPA 704
1
3 1

4-Hydroxypiperidine Chemical Properties,Uses,Production

Chemical Properties

yellow to yellow-orange wet solid

Uses

4-Hydroxypiperidine (4-Piperidinol) can be used in the synthesis of a highly potent and selective IP (PGI(2) receptor) agonist. It can also be used in the study of copper-catalyzed N- versus O-arylation.

Uses

4-Hydroxypiperidine is used as a reagent for the synthesis of acridine (A190900) derivatives and fibrinogen receptor antagonists.

General Description

The molecular structure, vibrational spectra, NBO and UV-spectral analysis of 4-Hydroxypiperidine have been studied. The compounds with a substituted 4-piperidinol core have been found to be potent antagonists of the human H(3) receptor.

Flammability and Explosibility

Not classified

4PPOL 4-HYDROXYPIPERIDINE HYDROXYPIPERIDINE(4-) AURORA KA-1006 4-Hydroxypiperidine base 4-Hydroxypiperidine, 99+% 4-HYDROXYPIPERIDINE=4-PIPERIDIOL 4-Hydroxypiperidine 98% 4-HYDROXY PIPERAZINE 4-Hydroxypiperidine/4-Piperidinol 4-HYDROXYPIPERIDINE 98.5% 4-Hydroxyhexahydropyridine 4-Piperidinol ,99% Piperidine-4α-ol Piperidine-4β-ol 4-Hydroxypiperidine, contains varying amountsof moisture,97% 4-Hydroxypiperidine, contains varying amounts of moisture, 97% 4-Hydropiperidine 4-piperidinyl 4-Hydroxypiperidine, 99+% 25GR 4-Hydroxypiperidine,97% 4-Hydroxypiperidine Vetec(TM) reagent grade, 98% 4-hydroxypiperdine 4-Piperidinol for synthesis 4-Hydroxypiperidine > 4-Hydroxypiperidine USP/EP/BP 4-Piperidinol/4-Hydroxypiperidine 4-Hydroxypiperidine(4HP) PIPERIDIN-4-OL 4-PIPERIDINOL Irinotecan Impurity 33 Ebastine Impurity 3 4-HYDROXYPIPERIDNE 5382-16-1 5382-16-2 6382-16-1 C5H11ClNO Building Blocks Heterocyclic Building Blocks Piperidines Building Blocks C5 to C7 Chemical Synthesis Heterocyclic Building Blocks Piperidines Piperidines, Piperidones, Piperazines Alcohols and Derivatives Amines and Anilines Pyrans, Piperidines &Piperazines Piperidine Heterocyclic Compounds NADIFLOXACIN Pyrans, Piperidines & Piperazines