1-benzyl-1H-pyrido[2,3-d][1,3]oxazine-2,4-dione synthesis
- Product Name:1-benzyl-1H-pyrido[2,3-d][1,3]oxazine-2,4-dione
- CAS Number:97484-73-6
- Molecular formula:C14H10N2O3
- Molecular Weight:254.24
33522-80-4
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$65.00/100mg
503-38-8
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$15.00/5g
97484-73-6
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$382.00/1g
Yield:97484-73-6 68%
Reaction Conditions:
in 1,4-dioxane; for 8 h;Heating / reflux;
Steps:
2
Trichloromethyl CHLOROFORMATE (2.5 mL, 21 mmol) was added slowly to a suspension of (1) (4 g, 17.5 mmol) in dioxane and refluxed for 8 h under nitrogen atmosphere. The solution was cooled and the solvent was removed under vacuum. The residue was dissolved in dichloromethane and washed by saturated NAHCO3 solution. The organic phase was dried over NA2SO4 and evaporated to yield a residue. The residue was recrystallized by ether to yiels 3.02 g (68 %) of 1-BENZYL, LH-PYRIDO [2,3- D] [1, 3] oxazine-2,4-dione (2) as white solids. MP: 168 °C ; 1H-NMR (DMSO-d6) : d 5.35 (s, 2H), 7.26 (m, 1H), 7.30 (m, 2H), 7.39 (m, 3H), 8.41 (dd, J= 1.5, 7.5 Hz, 1H), 8. 72 (dd, J = 1. 5,7. 5 Hz, 1H) ; EIMS : 277 (M+23).
References:
WO2005/21546,2005,A1 Location in patent:Page/Page column 112; 160
100-44-7
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$13.50/250G
![1H-pyrido[2,3-d][1,3]oxazine-2,4-dione](/CAS2/GIF/21038-63-1.gif)
21038-63-1
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$62.00/100mg
97484-73-6
14 suppliers
$382.00/1g
100-39-0
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$10.00/10g
97484-73-6
14 suppliers
$382.00/1g
5860-70-8
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$60.00/100mg
97484-73-6
14 suppliers
$382.00/1g