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Benzyl chloride

Benzyl chloride
Benzyl chloride structure
Chemical Name:
Benzyl chloride
gjgjg;Bzl-Cl;Benzile;Benzyle;NSC 8043;ai3-15518;C6H5CH2Cl;NCI-C06360;Benzylchlorid;tolylchloride
Molecular Formula:
Formula Weight:
MOL File:

Benzyl chloride Properties

Melting point:
-39 °C
Boiling point:
179 °C
1.1 g/mL at 25 °C(lit.)
vapor density 
4.36 (vs air)
vapor pressure 
10.3 mm Hg ( 60 °C)
refractive index 
n20/D 1.538(lit.)
Flash point:
165 °F
storage temp. 
soluble0.46g/L at 30°C (Decomposes in contact with water)
Clear colorless to slightly yellow
Pungent, irritating.
explosive limit
Water Solubility 
0.3 g/L (20 ºC)
Henry's Law Constant
(x 10-4 atm?m3/mol): 3.57 at 20.00 °C (inert gas stripping, Hovorka and Dohnal, 1997)
Exposure limits
TLV-TWA 1 ppm (~5mg/m3) (ACGIH, MSHA, and OSHA); IDLH 10 ppm (NIOSH); carcinogenicity: Animal Limited Evidence, Human Inadequate Evidence (IARC).
Unstable - inhibitors such as propylene oxide or trimethylamine are usually added to prevent polymerization. Combustible. Incompatible with strong oxidizing agents, water, acids, most common metals, dimethyl sulfoxide. Above flash point vapour-air mixtures are explosive within the limits noted above. Contact with water produces toxic fumes.
CAS DataBase Reference
100-44-7(CAS DataBase Reference)
EWG's Food Scores
2A (Vol. 29, Sup 7, 71) 1999
NIST Chemistry Reference
Benzyl chloride(100-44-7)
Proposition 65 List
Benzyl Chloride
EPA Substance Registry System
Benzyl chloride (100-44-7)
  • Risk and Safety Statements
Signal word  Danger
Hazard statements  H227-H314-H330-H370-H372-H400-H301-H302-H315-H317-H318-H331-H335-H350-H373-H340
Precautionary statements  P202-P210-P264-P270-P271-P273-P284-P301+P330+P331+P310-P303+P361+P353+P310+P363-P307+P311-P391-P403+P233-P405-P501-P201-P260-P280-P304+P340+P310-P305+P351+P338+P310-P308+P313-P304+P340+P312-P301+P310a-P303+P361+P353-P304+P340-P305+P351+P338-P320-P501a
Hazard Codes  T,T+
Risk Statements  45-22-23-37/38-41-48/22-43-26-46
Safety Statements  53-45-36/37/39-28-26-36/37
RIDADR  UN 1738 6.1/PG 2
WGK Germany  3
RTECS  XS8925000
Autoignition Temperature 585 °C
HazardClass  6.1
PackingGroup  II
HS Code  29039990
Toxicity LD50 orally in Rabbit: 440 mg/kg
NFPA 704
3 1

Benzyl chloride price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 185558 Benzyl chloride ReagentPlus , 99%, contains ≤1% propylene oxide as stabilizer 100-44-7 1kg $44.1 2020-08-18 Buy
Sigma-Aldrich 185558 Benzyl chloride ReagentPlus , 99%, contains ≤1% propylene oxide as stabilizer 100-44-7 2kg $101 2020-08-18 Buy
TCI Chemical B0412 Benzyl Chloride (stabilized with epsilon-Caprolactam) >99.0%(GC) 100-44-7 25g $13 2020-06-24 Buy
TCI Chemical B0412 Benzyl Chloride (stabilized with epsilon-Caprolactam) >99.0%(GC) 100-44-7 500g $18 2020-06-24 Buy
Alfa Aesar A12481 Benzyl chloride, 99%, stab. 100-44-7 500g $20.6 2020-06-24 Buy

Benzyl chloride Chemical Properties,Uses,Production

Chemical Properties

Benzyl chloride is a colorless to s lightly yellow liquid with a strong, unpleasant, irritating odor. The Odor Threshold is 0.05 ppm.The stabilized form of benzyl chloride contains a fixed amount of a sodium carbonate solution or propylene oxide.
benzyl chloride structure

Physical properties

Colorless to pale yellowish-brown liquid with a pungent, aromatic, irritating odor. Odor threshold concentration is 47 ppbv (Leonardos et al., 1969). Katz and Talbert (1930) reported an experimental detection odor threshold concentration of 210 μg/m3 (41 ppbv).


Benzyl chloride is used in the manufacture ofdyes, artificial resins, tanning agents, phar maceuticals, plasticizers, perfumes, lubri cants, and miscellaneous benyl compounds.


An intermediate in the preparation of phenylacetic acid (precursor to phamaceuticals). Also a precursor molecule to benzyl esters which are used as plasticizer, flavorants, and perfumes.


Benzyl chloride is a chemical intermediate in the manufacture of benzyl Compounds, perfumes, pharmaceutical products, dyes, plasticizers, synthetic tannins, artificial resins, and quaternary ammonium compounds.


ChEBI: A member of the class of benzyl chlorides that is toluene substituted on the alpha-carbon with chlorine.


2g benzyl alcohol and 6g concentrated hydrochloric acid were mixed and slowly heated. at 60°C the mixture separated into two layers. the yield of benzyl chloride was 70% of the theoretical. When the alcohol and a large excess of the acid were mixed, the reaction took place at the room temperature after a few minutes, and a theoretical yield of the chloride separated. Benzyl alcohol dissolves sparingly in hydrochloric acid of the specific gravity 1.12. when the solution is warmed, benzyl chloride is formed. Benzyl bromide and benzyl iodide were prepared in the same way from the corresponding acids.
benzyl chloride is a lachrymator, and a powerful one at that. In the presence of water, it hydrolyzes to benzyl alcohol and hydrochloric acid, so it's clear why it burns your water saturated eye so bad.

Production Methods

Benzyl chloride can be synthesized by chloromethylation of benzene in the presence of a catalyst (ZnCl2) or by treatment of benzyl alcohol with SO2Cl2. Commercially it is produced by chlorination of boiling toluene in the presence of light. Benzyl chloride can be oxidized to benzoic acid or benzaldehyde, or substituted to give the halogenated, sulfonated or nitrated product.With NH3 it yields mono-, di- or tribenzyl amine. With alcohols in base the benzylalkyl ether is formed. With phenols either the phenolic or nuclear hydrogens can react to give benzylaryl ether or benzylated phenols. Reaction with NaCN gives benzyl cyanide (phenylacetonitrile); with aliphatic primary amines the product is the N-alkylbenzylamine, and with aromatic primary amines N-benzylaniline is formed. Benzyl chloride is converted to butyl benzyl phthalate plasticizer and other chemicals.

Synthesis Reference(s)

The Journal of Organic Chemistry, 29, p. 3692, 1964 DOI: 10.1021/jo01035a504
Synthetic Communications, 16, p. 1173, 1986
Tetrahedron Letters, 29, p. 5783, 1988

General Description

A colorless liquid with an irritating odor. Toxic by inhalation and skin absorption. Flash point 153°F. Slightly soluble in water. Corrosive to metals and tissue. A lachrymator. Density 9.2 lb /gal.

Air & Water Reactions

A lachrymator. Slightly soluble in water.

Reactivity Profile

Halogenated aliphatic compounds, such as Benzyl chloride, are moderately or very reactive. Reactivity generally decreases with increased degree of substitution of halogen for hydrogen atoms. Materials in this group are incompatible with strong oxidizing and reducing agents. Also, they are incompatible with many amines, nitrides, azo/diazo compounds, alkali metals, and epoxides.


Highly toxic, intense eye and skin irritant. A lachrymator. Upper respiratory tract irritant. Prob- able carcinogen.

Health Hazard

Benzyl chloride is a corrosive liquid. Con tact with the eyes can cause corneal injury.Exposure to its vapors can produce intenseirritation of the eyes, nose, and throat. Highconcentrations may cause lung edema anddepression of the central nervous system.Flury and Zernik (1931) stated that exposureto 16 ppm for 1 minute was intolerable tohumans. The LC50 values for a 2-hour expo sure in mice and rats are 80 and 150 ppm,respectively. The subcutaneous LD50 valuein rats is 1000 mg/kg (NIOSH 1986).
Benzyl chloride tested positive to thehistidine reversion–Ames test for mutagenic ity. Subcutaneous administration of this com pound in laboratory animals caused tumors atthe site of application.

Fire Hazard

Benzyl chloride burns but does not ignite readily. Benzyl chloride may ignite combustibles. When heated to decomposition, Benzyl chloride emits toxic and corrosive fumes. Some organic chlorides decompose to yield phosgene. Incompatible with active metals such as copper, aluminum, magnesium, iron, zinc, and tin and keep from strong oxidizing agents. Avoid contact with acids or acid fumes. Keep separate from oxidizing materials. May become unstable at elevated temperatures and pressures; may react with water resulting in some nonviolent release of energy. Polymerizes with evolution of heat and hydrogen chloride when in contact with all common metals except nickel and lead.

Chemical Reactivity

Reactivity with Water Undergoes slow hydrolysis, liberating hydrogen chloride (hydrochloric acid); Reactivity with Common Materials: Decomposes rapidly in the presence of all common metals (with the exception of nickel and lead), liberating heat and hydrogen chloride; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Rinse with sodium bicarbonate or lime solution; Polymerization: Polymerizes with evolution of heat and hydrogen chloride when in contact with all common metals except nickel and lead; Inhibitor of Polymerization: Triethylamine, propylene oxide or sodium carbonate.

Potential Exposure

Used as an intermediate and as an irritant gas in chemical warfare. In contrast to phenyl halides, benzyl halides are very reactive. Benzyl chloride is used in production of benzal chloride, benzyl alcohol, and benzaldehyde. Industrial usage includes the manufacture of benzyl compounds, cosmetics, dyes, plastics, synthetic tannins, perfumes and resins. It is used in the manufacture of many pharmaceuticals. Suggested uses of benzyl chloride include: the vulcanization of fluororubbers and the benzylation of phenol and its derivatives for the production of possible disinfectants.


Benzyl chloride caused genetic mutations and chromosome-damaging effects in a wide variety of in vitro assays; it was not mutagenic in vivo in the mouse micronucleus assay


As of October 1996, benzyl chloride was listed for regulation but no MCLGs or MCLs have been proposed (U.S. EPA, 1996).
Reported as an impurity (≤ 0.05 wt %) in 98.5 wt % benzyl mercpatan (Chevron Phillips, April 2005).

Environmental Fate

Biological. When incubated with raw sewage and raw sewage acclimated with hydrocarbons, benzyl chloride degraded forming nonchlorinated products (Jacobson and Alexander, 1981).
Chemical/Physical. Anticipated products from the reaction of benzyl chloride with ozone or OH radicals in the atmosphere are chloromethyl phenols, benzaldehyde and chlorine radicals (Cupitt, 1980).
Slowly hydrolyzes in water forming HCl and benzyl alcohol. The estimated hydrolysis half-life in water at 25 °C and pH 7 is 15 h (Mabey and Mill, 1978). The hydrolysis rate constant for benzyl chloride at pH 7 and 59.2 °C was determined to be 0.0204/min, resulting in a half-life of 34 min (Ellington et al., 1986).
May polymerize in contact with metals except nickel and lead (NIOSH, 1997).
When heated to decomposition, hydrogen chloride gas may be released (CHRIS, 1984).


UN1738 Benzyl chloride, Hazard class: 6.1; Labels: 6.1—Poisonous materials, 8—Corrosive material.

Purification Methods

Dry it with MgSO4 or CaSO4, or reflux it with fresh Ca turnings, then fractionally distil it under reduced pressure, collecting the middle fraction and storing it over CaH2 or P2O5. It has also been purified by passage through a column of alumina. Alternatively it is dried over MgSO4 and distilled in a vacuum. The middle fraction is degassed by several freeze-thaw cycles and then fractionated in an 'isolated fractionating column' (which has been evacuated and sealed off at ~10-6 mm) over a steam bath. The middle fraction is retained. The final samples are distilled in a vacuum from this sample and again retaining the middle fraction. The purity is >99.9% (no other peaks are visible by GLC, and the NMR spectrum is consistent with the structure. [Mohammed & Kosower J Am Chem Soc 93 1709 1971, Beilstein 5 IV 809.] IRRITANT and strongly LACHRYMATORY.


May form explosive mixture with air. Contact with water forms hydrogen chloride fumes. Strong oxidizers may cause fire and explosions. Unstabilized benzyl chloride undergoes polymerization with copper, aluminum, iron, zinc, magnesium, tin, and other common metals except lead and nickel, with the liberation of heat and hydrogen chloride gas. May accumulate static electrical charges, and may cause ignition of its vapors. Attacks some plastics and rubber. Thermal decomposition and polymerization reactions are inhibited, to a limited extent, by addition of triethylamine, propylene oxide, or sodium carbonate.

Waste Disposal

Incineration @ 816 C for 0.5 second minimum for primary combustion and 1204 C for 12.0 second for secondary combustion. Elemental chlorine formation may be alleviated by injection of steam or methane into the combustion process.

Benzyl chloride Preparation Products And Raw materials

Raw materials

Preparation Products

Benzyl chloride Suppliers

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View Lastest Price from Benzyl chloride manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2020-07-07 Benzyl chloride
10ASSAYS 99.6% 600kg/month Hebei Huanhao Biotechnology Co., Ltd.
2020-07-07 Benzyl chloride
US $100.00 / KG 1KG 99% 10000 Kilogram/Kilograms per Month Hebei Xibaijie Biotechnology Co., Ltd.
2019-07-24 Benzyl chloride
US $1.95 / KG 1KG 99.50% in stock 2000.00 MT per month Chemwill Asia Co.,Ltd.

Benzyl chloride Spectrum

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