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Benzyl chloride

Benzyl chloride
Benzyl chloride structure
CAS No.
100-44-7
Chemical Name:
Benzyl chloride
Synonyms
Bzl-Cl;Benzile;Benzyle;NSC 8043;ai3-15518;C6H5CH2Cl;NCI-C06360;Benzylchlorid;tolylchloride;α-Chlortoluol
CBNumber:
CB1852583
Molecular Formula:
C7H7Cl
Formula Weight:
126.58
MOL File:
100-44-7.mol

Benzyl chloride Properties

Melting point:
-39 °C
Boiling point:
179 °C
Density 
1.1 g/mL at 25 °C(lit.)
vapor density 
4.36 (vs air)
vapor pressure 
10.3 mm Hg ( 60 °C)
refractive index 
n20/D 1.538(lit.)
Flash point:
165 °F
storage temp. 
0-6°C
solubility 
soluble0.46g/L at 30°C (Decomposes in contact with water)
form 
Liquid
color 
Clear colorless to slightly yellow
Odor
Pungent, irritating.
explosive limit
1.1-14%(V)
Water Solubility 
0.3 g/L (20 ºC)
Merck 
14,1129
BRN 
471308
Exposure limits
TLV-TWA 1 ppm (~5mg/m3) (ACGIH, MSHA, and OSHA); IDLH 10 ppm (NIOSH); carcinogenicity: Animal Limited Evidence, Human Inadequate Evidence (IARC).
Stability:
Unstable - inhibitors such as propylene oxide or trimethylamine are usually added to prevent polymerization. Combustible. Incompatible with strong oxidizing agents, water, acids, most common metals, dimethyl sulfoxide. Above flash point vapour-air mixtures are explosive within the limits noted above. Contact with water produces toxic fumes.
InChIKey
KCXMKQUNVWSEMD-UHFFFAOYSA-N
CAS DataBase Reference
100-44-7(CAS DataBase Reference)
NIST Chemistry Reference
Benzyl chloride(100-44-7)
EPA Substance Registry System
Benzene, (chloromethyl)-(100-44-7)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
  • NFPA
Hazard Codes  T,T+
Risk Statements  45-22-23-37/38-41-48/22-43-26-46
Safety Statements  53-45-36/37/39-28-26-36/37
RIDADR  UN 1738 6.1/PG 2
WGK Germany  3
RTECS  XS8925000
8-19
Autoignition Temperature 585 °C
TSCA  Yes
HazardClass  6.1
PackingGroup  II
HS Code  29039990
Hazardous Substances Data 100-44-7(Hazardous Substances Data)
Toxicity LD50 orally in Rabbit: 440 mg/kg
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H227 Combustible liquid Flammable liquids Category 4 Warning P210, P280, P370+P378, P403+P235,P501
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger P264, P270, P301+P310, P321, P330,P405, P501
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H314 Causes severe skin burns and eye damage Skin corrosion/irritation Category 1A, B, C Danger P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H318 Causes serious eye damage Serious eye damage/eye irritation Category 1 Danger P280, P305+P351+P338, P310
H330 Fatal if inhaled Acute toxicity,inhalation Category 1, 2 Danger P260, P271, P284, P304+P340, P310,P320, P403+P233, P405, P501
H331 Toxic if inhaled Acute toxicity,inhalation Category 3 Danger P261, P271, P304+P340, P311, P321,P403+P233, P405, P501
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
H340 May cause genetic defects Germ cell mutagenicity Category 1A, 1B Danger
H350 May cause cancer Carcinogenicity Category 1A, 1B Danger
H370 Causes damage to organs Specific target organ toxicity, single exposure Category 1 Danger P260, P264, P270, P307+P311, P321,P405, P501
H372 Causes damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 1 Danger P260, P264, P270, P314, P501
H373 May cause damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 2 Warning P260, P314, P501
H400 Very toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 1 Warning P273, P391, P501
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P284 Wear respiratory protection.
P320 Specific treatment is urgent (see … on this label).
P391 Collect spillage. Hazardous to the aquatic environment
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P307+P311 IF exposed: call a POISON CENTER or doctor/physician.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P405 Store locked up.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P501 Dispose of contents/container to..…

NFPA 704

Diamond Hazard Value Description
2
3 1
Health   3 Short exposure could cause serious temporary or moderate residual injury (e.g. liquid hydrogen, sulfuric acid, calcium hypochlorite, hexafluorosilicic acid)
Flammability   2 Must be moderately heated or exposed to relatively high ambient temperature before ignition can occur and multiple finely divided suspended solids that do not require heating before ignition can occur. Flash point between 37.8 and 93.3 °C (100 and 200 °F). (e.g. diesel fuel, sulfur)
Instability   1 Normally stable, but can become unstable at elevated temperatures and pressures (e.g. propene)
Special  

(NFPA, 2010)

Benzyl chloride price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 185558 Benzyl chloride ReagentPlus , 99%, contains ≤1% propylene oxide as stabilizer 100-44-7 1kg $42.3 2018-11-13 Buy
Sigma-Aldrich 185558 Benzyl chloride ReagentPlus , 99%, contains ≤1% propylene oxide as stabilizer 100-44-7 2kg $92 2018-11-13 Buy
TCI Chemical B0412 Benzyl Chloride (stabilized with epsilon-Caprolactam) >99.0%(GC) 100-44-7 25g $12 2018-11-22 Buy
TCI Chemical B0412 Benzyl Chloride (stabilized with epsilon-Caprolactam) >99.0%(GC) 100-44-7 500g $17 2018-11-22 Buy
Alfa Aesar A12481 Benzyl chloride, 99%, stab. 100-44-7 500g $19.4 2018-11-13 Buy

Benzyl chloride Chemical Properties,Uses,Production

Chemical Properties

Colorless to yellow liquid

Chemical Properties

Benzyl chloride is a colorless to s lightly yellow liquid with a strong, unpleasant, irritating odor. The Odor Threshold is 0.05 ppm.

Uses

Benzyl chloride is used in the manufacture ofdyes, artificial resins, tanning agents, phar maceuticals, plasticizers, perfumes, lubri cants, and miscellaneous benyl compounds.

Uses

An intermediate in the preparation of phenylacetic acid (precursor to phamaceuticals). Also a precursor molecule to benzyl esters which are used as plasticizer, flavorants, and perfumes.

Uses

manufacture of benzyl Compounds, perfumes, pharmaceutical products, dyes, synthetic tannins, artificial resins.

Definition

ChEBI: A member of the class of benzyl chlorides that is toluene substituted on the alpha-carbon with chlorine.

General Description

A colorless liquid with an irritating odor. Toxic by inhalation and skin absorption. Flash point 153°F. Slightly soluble in water. Corrosive to metals and tissue. A lachrymator. Density 9.2 lb /gal.

Air & Water Reactions

A lachrymator. Slightly soluble in water.

Reactivity Profile

Halogenated aliphatic compounds, such as Benzyl chloride, are moderately or very reactive. Reactivity generally decreases with increased degree of substitution of halogen for hydrogen atoms. Materials in this group are incompatible with strong oxidizing and reducing agents. Also, they are incompatible with many amines, nitrides, azo/diazo compounds, alkali metals, and epoxides.

Hazard

Highly toxic, intense eye and skin irritant. A lachrymator. Upper respiratory tract irritant. Prob- able carcinogen.

Health Hazard

Benzyl chloride is a corrosive liquid. Con tact with the eyes can cause corneal injury.Exposure to its vapors can produce intenseirritation of the eyes, nose, and throat. Highconcentrations may cause lung edema anddepression of the central nervous system.Flury and Zernik (1931) stated that exposureto 16 ppm for 1 minute was intolerable tohumans. The LC50 values for a 2-hour expo sure in mice and rats are 80 and 150 ppm,respectively. The subcutaneous LD50 valuein rats is 1000 mg/kg (NIOSH 1986).
Benzyl chloride tested positive to thehistidine reversion–Ames test for mutagenic ity. Subcutaneous administration of this com pound in laboratory animals caused tumors atthe site of application.

Health Hazard

Intensely irritating to skin, eyes, and mucous membranes. Highly toxic; may cause death or permanent injury after very short exposure to small quantities. Has been listed as a direct-acting or primary carcinogen. Large doses cause central nervous system depression.

Fire Hazard

Benzyl chloride burns but does not ignite readily. Benzyl chloride may ignite combustibles. When heated to decomposition, Benzyl chloride emits toxic and corrosive fumes. Some organic chlorides decompose to yield phosgene. Incompatible with active metals such as copper, aluminum, magnesium, iron, zinc, and tin and keep from strong oxidizing agents. Avoid contact with acids or acid fumes. Keep separate from oxidizing materials. May become unstable at elevated temperatures and pressures; may react with water resulting in some nonviolent release of energy. Polymerizes with evolution of heat and hydrogen chloride when in contact with all common metals except nickel and lead.

Fire Hazard

Flash Point (°F): 165 ℃, 140 ℃; Flammable Limits in Air (%): 1.1 (LEL); Fire Extinguishing Agents: Water, dry chemical, foam, and carbon dioxide; Fire Extinguishing Agents Not To Be Used: Not pertinent; Special Hazards of Combustion Products: Irritating hydrogen chloride gas forms; Behavior in Fire: Forms vapor that is a powerful tear gas; Ignition Temperature (°F): 1,161; Electrical Hazard: No data; Burning Rate: 4.2 mm/min.

Chemical Reactivity

Reactivity with Water Undergoes slow hydrolysis, liberating hydrogen chloride (hydrochloric acid); Reactivity with Common Materials: Decomposes rapidly in the presence of all common metals (with the exception of nickel and lead), liberating heat and hydrogen chloride; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Rinse with sodium bicarbonate or lime solution; Polymerization: Polymerizes with evolution of heat and hydrogen chloride when in contact with all common metals except nickel and lead; Inhibitor of Polymerization: Triethylamine, propylene oxide or sodium carbonate.

Potential Exposure

Used as an intermediate and as an irritant gas in chemical warfare. In contrast to phenyl halides, benzyl halides are very reactive. Benzyl chloride is used in production of benzal chloride, benzyl alcohol, and benzaldehyde. Industrial usage includes the manufacture of plastics, dyes, synthetic tannins, perfumes and resins. It is used in the manufacture of many pharmaceuticals. Suggested uses of benzyl chloride include: the vulcanization of fluororubbers and the benzylation of phenol and its derivatives for the production of possible disinfectants.

First aid

If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. If victim is conscious, administer water or milk. Do not induce vomiting. Medical observation is recommended for 24 to 48 hours after breathing overexposure, as pulmonary edema may be delayed. As first aid for pulmonary edema, a doctor or authorized paramedic may consider administering a drug or other inhalation therapy.

Shipping

UN1738 Benzyl chloride, Hazard class: 6.1; Labels: 6.1—Poisonous materials, 8—Corrosive material.

Purification Methods

Dry it with MgSO4 or CaSO4, or reflux it with fresh Ca turnings, then fractionally distil it under reduced pressure, collecting the middle fraction and storing it over CaH2 or P2O5. It has also been purified by passage through a column of alumina. Alternatively it is dried over MgSO4 and distilled in a vacuum. The middle fraction is degassed by several freeze-thaw cycles and then fractionated in an 'isolated fractionating column' (which has been evacuated and sealed off at ~10-6 mm) over a steam bath. The middle fraction is retained. The final samples are distilled in a vacuum from this sample and again retaining the middle fraction. The purity is >99.9% (no other peaks are visible by GLC, and the NMR spectrum is consistent with the structure. [Mohammed & Kosower J Am Chem Soc 93 1709 1971, Beilstein 5 IV 809.] IRRITANT and strongly LACHRYMATORY.

Incompatibilities

May form explosive mixture with air. Contact with water forms hydrogen chloride fumes. Strong oxidizers may cause fire and explosions. Unstabilized benzyl chloride undergoes polymerization with copper, aluminum, iron, zinc, magnesium, tin, and other common metals except lead and nickel, with the liberation of heat and hydrogen chloride gas. May accumulate static electrical charges, and may cause ignition of its vapors. Attacks some plastics and rubber. Thermal decomposition and polymerization reactions are inhibited, to a limited extent, by addition of triethylamine, propylene oxide, or sodium carbonate.

Waste Disposal

Incineration @ 816 C for 0.5 second minimum for primary combustion and 1204 C for 12.0 second for secondary combustion. Elemental chlorine formation may be alleviated by injection of steam or methane into the combustion process.

Benzyl chloride Preparation Products And Raw materials

Raw materials

Preparation Products


Benzyl chloride Suppliers

Global( 284)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Hebei Guanlang Biotechnology Co., Ltd.
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Henan DaKen Chemical CO.,LTD.
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Mainchem Co., Ltd.
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86-0551-65418684 18949823763
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Hubei Jusheng Technology Co.,Ltd.
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QUALITY CONTROL CHEMICALS INC.
(323) 306-3136
(626) 453-0409 orders@qcchemical.com United States 8409 58

View Lastest Price from Benzyl chloride manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-18 Benzyl chloride
100-44-7
US $2.00 / kg 1kg 99% ask career henan chemical co
2019-04-25 Benzyl chloride
202-853-6
US $10.00 / kg 1kg 99% 500tons/month Hebei Chisure Biotechnology Co., Ltd.
2018-10-15 Benzyl chloride
100-44-7
US $120.00 / G 10G 99.6% 600kg/month Hebei Huanhao Biotechnology Co., Ltd.

Benzyl chloride Spectrum


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