(1-BENZYL-2-SULFANYL-1H-IMIDAZOL-5-YL)METHANOL synthesis
- Product Name:(1-BENZYL-2-SULFANYL-1H-IMIDAZOL-5-YL)METHANOL
- CAS Number:98412-23-8
- Molecular formula:C11H12N2OS
- Molecular Weight:220.29
96-26-4
497 suppliers
$9.00/10g
333-20-0
459 suppliers
$13.50/100G
100-46-9
495 suppliers
$5.00/5G
98412-23-8
27 suppliers
$45.00/50mg
Yield:98412-23-8 98%
Reaction Conditions:
with hydrogenchloride;propionic acid in water monomer;acetonitrile at 70; for 3 h;
Steps:
2.2. General Procedure for the Synthesis of Compounds10 and 11
General procedure: To a stirring solution of appropriate amines (30 mmol) inacetonitrile (30 mL), 37% HCl was added (2.5 mL, 30mmol) at 0 °C, which formed a white solid in 3 minutes.Then propionic acid (2.5 mL), dihydroxyacetone (4.5 g, 25mmol), and KSCN (2.9 g, 30 mmol) were added. The reactionmixture was refluxed at 70 °C for 3 hours. The formedprecipitate was filtered and washed with water and ethanol togive compounds 10 and 11.(1-benzyl-2-mercapto-1H-imidazol-5-yl)methanol (10).Yield 98%; 229.4 °C; IR (CCl3) υ (cm-1) 2030-3484 (O-Halcoholic), LC-MS (ESI) m/z 221.0000 (M+H+).
References:
Karimi, Nafiseh;Roudsari, Rouhollah Vahabpour;Hajimahdi, Zahra;Zarghi, Afshin [Medicinal Chemistry,2022,vol. 18,# 5,p. 616 - 628]
108-20-3
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$25.00/25mL
62147-49-3
130 suppliers
$10.00/10g
39110-74-2
35 suppliers
inquiry
98412-23-8
27 suppliers
$45.00/50mg
62147-49-3
130 suppliers
$10.00/10g
39110-74-2
35 suppliers
inquiry
333-20-0
459 suppliers
$13.50/100G
98412-23-8
27 suppliers
$45.00/50mg
62147-49-3
130 suppliers
$10.00/10g
100-46-9
495 suppliers
$5.00/5G
71-36-3
1071 suppliers
$14.00/25mL
98412-23-8
27 suppliers
$45.00/50mg
96-26-4
497 suppliers
$9.00/10g
39110-74-2
35 suppliers
inquiry
333-20-0
459 suppliers
$13.50/100G
98412-23-8
27 suppliers
$45.00/50mg