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Isopropyl ether

Isopropyl ether
Isopropyl ether structure
Chemical Name:
Isopropyl ether
DIPE;(iso-C3H7)2O;Isoprpyl ether;Isopropyl ethe;Diisopropyleth;Isopropyl oxide;ether,isopropyl;ISOPROPYL ETHER;Diisoproyl ether;diisopropyloxide
Molecular Formula:
Formula Weight:
MOL File:

Isopropyl ether Properties

Melting point:
-85.5 °C
Boiling point:
68-69 °C(lit.)
0.725 g/mL at 25 °C(lit.)
vapor density 
3.5 (vs air)
vapor pressure 
120 mm Hg ( 20 °C)
refractive index 
n20/D 1.367(lit.)
Flash point:
−29 °F
storage temp. 
Store below +30°C.
APHA: ≤25
Relative polarity
Sweet, slightly sharp; characteristic pungent; ethereal; like amphor and ethyl ether.
explosive limit
1-21%, 100°F
Water Solubility 
9 g/L (20 ºC)
Henry's Law Constant
2.57 at 25 °C (headspace-GC, Arp and Schmidt, 2004)
Exposure limits
TLV-TWA 1045 mg/m3 (250 ppm) (ACGIH), 2090 mg/m3 (500 ppm) (OSHA); STEL 1300 mg/m3 (310 ppm) (ACGIH).
Stability Extremely flammable. This material is a serious fire and explosion risk. Vapour may travel considerable distances to an ignition source, which need not be an open flame, but may be a hot plate, steam pipe, etc. Vapour may be ignited by the static electricty which can build up when isopropyl ether is being poured from one vessel
CAS DataBase Reference
108-20-3(CAS DataBase Reference)
EWG's Food Scores
NIST Chemistry Reference
Diisopropyl ether(108-20-3)
EPA Substance Registry System
Isopropyl ether (108-20-3)
  • Risk and Safety Statements
Signal word  Danger
Hazard statements  H225-H336
Precautionary statements  P210-P370+P378-P403+P235
Hazard Codes  F
Risk Statements  11-19-66-67-52/53
Safety Statements  9-16-29-33-61
RIDADR  UN 1159 3/PG 2
WGK Germany  1
RTECS  TZ5425000
Autoignition Temperature 827 °F
HS Code  2909 19 90
HazardClass  3
PackingGroup  II
Toxicity LD50 in 14 day old, young adult, adult rats (ml/kg): 6.4, 16.5, 16.0 orally (Kimura)
NFPA 704
1 1

Isopropyl ether price More Price(61)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.45123 Diisopropyl ether (stabilised with BHT) Msynth?plus 108-20-3 1 L $37.65 2021-12-16 Buy
Sigma-Aldrich 8.00866 Diisopropyl ether (stabilized with 2,6-di-tert-butyl-4-methylphenol (BHT)) for synthesis 108-20-3 1 L $43.1 2021-12-16 Buy
Sigma-Aldrich 8.45123 Diisopropyl ether (stabilised with BHT) Msynth?plus 108-20-3 2.5 L $54.2 2021-12-16 Buy
Sigma-Aldrich 1.00867 Diisopropyl ether for analysis EMSURE? ACS,Reag. Ph Eur 108-20-3 1 L $81.86 2021-12-16 Buy
Sigma-Aldrich 185302 Diisopropyl ether ReagentPlus , 99%, contains either BHT or hydroquinone as stabilizer 108-20-3 1l $84.2 2021-12-16 Buy

Isopropyl ether Chemical Properties,Uses,Production


Isopropyl ether (diisopropyl ether) is highly flammable, with a wide flammable range of 1.4%–21% in air. Boiling point is 156°F (68°C), flash point is ?18°F (?27°C), and ignition temperature is 830°F (443°C). Vapor density is 3.5, which is heavier than air. In addition to flammability, isopropyl ether is toxic by inhalation and a strong irritant, with a TLV of 250 ppm in air.

Chemical Properties

colourless liquid

Physical properties

Clear, colorless, volatile, flammable liquid with a penetrating, sweet, ether-like odor. Experimentally determined detection and recognition odor threshold concentrations were 70 μg/m3 (17 ppbv) and 220 μg/m3 (53 ppbv), respectively (Hellman and Small, 1974).


Isopropyl ether is used as a solvent for oils,waxes, resins, and dyes; and as a varnishremover.


Solvent; chemical intermediate


As solvent; fuel additive.

General Description

A clear colorless liquid with an ethereal odor. Flash point -18°F. Less dense than water. Vapors heavier than air.

Air & Water Reactions

Highly flammable. Slightly soluble in water. Form explosive peroxide in storage. A flask of Isopropyl ether was heated on a steam bath with gentle shaking when an explosion occurred. In a second instance, an explosion occurred after practically all the ether had been distilled, [MCA Guide for Safety(1972)].

Reactivity Profile

Ethers, such as Isopropyl ether, can act as bases. They form salts with strong acids and addition complexes with Lewis acids. The complex between diethyl ether and boron trifluoride is an example. Ethers may react violently with strong oxidizing agents. In other reactions, which typically involve the breaking of the carbon-oxygen bond, ethers are relatively inert. Mixing Isopropyl ether in equal molar portions with any of the following substances in a closed container caused the temperature and pressure to increase: chlorosulfonic acid, nitric acid, [NFPA 1991].


Flammable, dangerous fire risk, explosive limits in air 1.4–21%. Toxic by inhalation, strong irritant.

Health Hazard

Inhalation causes anesthesia, nausea, headache, dizziness, and irritation of the eyes and nose. Contact of liquid with eyes causes only minor injury; repeated contact with skin will remove natural oils and may cause dermatitis.

Health Hazard

Isopropyl ether is a narcotic and an irritant tothe skin and mucous membranes. It is moretoxic than ethyl ether and the toxic symptomsare similar to the latter compound. Inhalationof its vapors can produce anesthetic effects.Exposure to high concentrations can causeintoxication, respiratory arrest, and death.Exposure to 3.14% and 2.9% of isopropylether in air (by volume) produced the symp toms of somnolence, change in motor activ ity, and muscle contractions in mice andrabbits, respectively, causing the death of50% of test animals. Exposure to 7–10% byvolume concentration in air can be fatal tohumans
Acute oral toxicity of isopropyl ether islow. The liquid is irritating to the mucousmembranes. Skin contact may cause mildirritation, and repeated exposure may causedermatitis. The irritation effect of isopropylether on eyes is mild. In humans, exposureto 800 ppm in air for a few minutes causedirritation of the eyes and nose. There is noreport of its carcinogenic action in animalsor humans.

Fire Hazard

Behavior in Fire: Vapor is heavier than air and may travel a considerable distance to a source of ignition and flash back. Containers may explode when heated.

Chemical Reactivity

Reactivity with Water: No reaction; Reactivity with Common Materials: No reactions; Stability During Transport: Unstable peroxides may form if the product contacts air for long time periods. These may explode spontaneously or when heated; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.

Industrial uses

Isopropyl ether is a solvent of minor importance since its boiling point is intermediate between the two widely used solvents diethyl ether and acetone. Hazardous peroxides are formed more readily in isopropyl ether than in other dialkyl ethers.


Some unleaded gasoline may contain isopropyl ether and other oxygenates as an octane booster and to prevent engine knock.

Environmental Fate

Biological. Bridié et al. (1979) reported BOD and COD values of 0.19 and 1.75 g/g using filtered effluent from a biological sanitary waste treatment plant. These values were determined using a standard dilution method at 20 °C and stirred for a period of 5 d. The ThOD for isopropyl ether is 2.82 g/g.
Chemical/Physical. May form explosive peroxides on standing with air (NIOSH, 1997). At an influent concentration of 1,018 mg/L, treatment with GAC resulted in an effluent concentration of 203 mg/L. The adsorbability of the GAC used was 162 mg/g carbon (Guisti et al., 1974).
Isopropyl will not hydrolyze in water except at elevated temperatures and low pH.


Isopropyl ether is stored in a flammable-liquids storage room, isolated from combustible and oxidizing materials. It shouldalso be protected from direct sunlight, staticelectricity, and lightning. It is stabilized with0.01% hydroquinone or p-benzylaminphenol.The ether is shipped in amber glass bottles,steel cans, and drums.

Purification Methods

Common impurities are water and peroxides [detected by the liberation of iodine from weakly acid (HCl) solutions of 2% KI]. Peroxides can be removed by shaking with aqueous Na2SO3 or with acidified ferrous sulfate (0.6g FeSO4 and 6mL conc H2SO4 in 110mL of water, using 5-10g of solution per L of ether), or aqueous NaBH4 solution. The ether is then washed with water, dried with CaCl2 and distilled. Alternatively, refluxing with LiAlH4 or CaH2, or drying with CaSO4, then passage through an activated alumina column, can be used to remove water and peroxides. Other dehydrating agents used with isopropyl ether include P2O5, sodium amalgam and sodium wire. (The ether is often stored in brown bottles, or in the dark, with sodium wire.) Bonner and Goishi (J Am Chem Soc 83 85 1961) treated isopropyl ether with dilute sodium dichromate/sulfuric acid solution, followed by repeated shaking with a 1:1 mixture of 6M NaOH and saturated KMnO4. The ether is washed several times with water, dilute aqueous HCl, and water, with a final washing with, and storage over, ferrous ammonium sulfate acidified with H2SO4. Blaustein and Gryder (J Am Chem Soc 79 540 1957), after washing with alkaline KMnO4, then water, treated the ether with ceric nitrate in nitric acid, and again washed it with water. Hydroquinone is added before drying with CaCl2 and MgSO4, and refluxing with sodium amalgam (108g Hg/100g Na) for 2hours under nitrogen. The distillate (nitrogen atmosphere) is made 2 x 10-5M in hydroquinone to inhibit formation of peroxides (which is negligible if the ether is stored in the dark). Catechol (pyrocatechol) and resorcinol are alternative inhibitors. [Beilstein 1 IV 1471.]

Waste Disposal

Isopropyl ether is burned in a chemicalincinerator equipped with an afterburner andscrubber. A small amount of ether, if free ofperoxides, can be evaporated in a fume hoodin the absence of any open flame or sourceof ignition nearby.

Isopropyl ether Preparation Products And Raw materials

Raw materials

Preparation Products

Isopropyl ether Suppliers

Global( 328)Suppliers
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View Lastest Price from Isopropyl ether manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2022-01-22 Isopropyl ether
US $19.00 / Kg/Bag 1KG 99% 22kg Hong Kong Tiansheng New Material Trading Co., Ltd
2022-01-22 Isopropyl ether
US $8.20 / KG 1KG 99% 1000tons Hong Kong Tiansheng New Material Trading Co., Ltd
2021-12-01 Isopropyl ether
US $10.70 / Kg/Drum 10g 99% 10000kg Hebei Crovell Biotech Co Ltd

Isopropyl ether Spectrum

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