1-Benzyl-3-chloro-piperidine synthesis
- Product Name:1-Benzyl-3-chloro-piperidine
- CAS Number:54436-59-8
- Molecular formula:C12H16ClN
- Molecular Weight:209.72
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Yield:54436-59-8 82%
Reaction Conditions:
with copper(II) choride dihydrate in tetrahydrofuran at 20; for 21 h;Reflux;
Steps:
4.4. One-pot two-step preparation of 3-chloropiperidines
General procedure: The reaction was carried out in open air system. To a 100 mL flask were added 1 mmol alkenylamine, 100 mol % CuCl2*2H2O,and 20 mL of THF. The reaction mixture was stirred at room temperature for 3 h, and then refluxed for 18 h. After cooling to room temperature, the reaction mixture was washed with water (25 mL x 3), dried over MgSO4, and was concentrated to give an oil. Flash column chromatography (petroleum ether/ethylacetate=100:1) gave the corresponding products.
References:
Li, Run-Lin;Liu, Gong-Qing;Li, Wei;Wang, Yu-Mei;Li, Lin;Duan, Lili;Li, Yue-Ming [Tetrahedron,2013,vol. 69,# 29,p. 5867 - 5873]
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