1-BENZYLPIPERIDINE-3-CARBOXYLIC ACID synthesis
- Product Name:1-BENZYLPIPERIDINE-3-CARBOXYLIC ACID
- CAS Number:141943-04-6
- Molecular formula:C13H17NO2
- Molecular Weight:219.28
72551-53-2
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141943-04-6
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Yield:141943-04-6 100%
Reaction Conditions:
with sodium hydroxide in tetrahydrofuran;1,4-dioxane;water at 20;
Steps:
138.b Example 138; Synthesis of N-(1-benzylpiperidin-3-yl)-1H-indazole-5-carboxamide; (b) Synthesis of 1-benzyl-3-piperidinecarboxylic acid
A 4N-aqueous sodium hydroxide solution (15 ml) was added to a solution of ethyl 1-benzyl-3-piperidinecarboxylate (7.00 g, 28.3 mmol) in a mixture of tetrahydrofuran (30 ml) and 1,4-dioxane (30 ml), and the resulting mixture was stirred at room temperature for 4 hours. After a 4N-aqueous sodium hydroxide solution (15 ml) was added again, the resulting mixture was stirred overnight at room temperature. After completion of the reaction, the reaction solution was neutralized by the addition of 2N-hydrochloric acid (15 ml) under ice-cooling and the resulting mixture was subjected to azeotropic concentration with toluene. The residue was suspended in ethanol, followed by filtration, and the filtrate was concentrated to obtain 1-benzyl-3-piperidinecarboxylic acid (6.3 g, 100%).
References:
EP1403255,2004,A1 Location in patent:Page 66
141943-03-5
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498-95-3
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71962-74-8
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100-44-7
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384 suppliers
$5.00/5g
141943-04-6
54 suppliers
$60.00/250mg
100-44-7
662 suppliers
$13.50/250G
141943-04-6
54 suppliers
$60.00/250mg