1-BOC-3-(4-FLUOROPHENYL)-3-HYDROXYPYRROLIDINE synthesis
- Product Name:1-BOC-3-(4-FLUOROPHENYL)-3-HYDROXYPYRROLIDINE
- CAS Number:1003560-58-4
- Molecular formula:C15H20FNO3
- Molecular Weight:281.32
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Yield:-
Reaction Conditions:
in tetrahydrofuran;diethyl ether at 20; for 0.583333 h;
Steps:
216
A solution of 4-fluorophenylmagnesium bromide (1M in THF, 11 mL, 11 mmol) was added gradually to a solution of tert-butyl 3-oxopyrrolidine-1-carboxylate (1.85 g, 10 mmol) in diethyl ether (40 mL) during 5 min at ambient temperature. The mixture was stirred for 30 min and thereafter slowly quenched with NH3Cl (10 mL, 3M). The organic phase was isolated and evaporated. The residue was purified by flash chromatography (SiO2 2:1 heptane/EtOAc) to afford the title compound, which was used without further purification. MS (EI) 208 (M-tBuO)
References:
US2008/21022,2008,A1 Location in patent:Page/Page column 96
101385-93-7
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1003560-58-4
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