1-Boc-4-(2-chloro-4-nitrophenyl)piperazine synthesis
- Product Name:1-Boc-4-(2-chloro-4-nitrophenyl)piperazine
- CAS Number:193902-80-6
- Molecular formula:C15H20ClN3O4
- Molecular Weight:341.79
24424-99-5
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$13.50/25G
114878-60-3
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$12.00/250mg
193902-80-6
13 suppliers
$24.05/250mg
Yield:193902-80-6 86%
Reaction Conditions:
with dmap;triethylamine in dichloromethane at 20;
Steps:
7
According to Scheme 5 Step 1 : A solution of l-(2-chloro-4-nitrophenyl)piperazine (2.90 mmol, 700 mg), BoC2O (3.19 mmol, 0.96 mL), Et3N (3.48 mmol, 0.49 mL) and of DMAP (0.29 mmol, 35 mg) in DCM (5 mL) was stirred at room temperature overnight. The organic phase was washed once with HCl 0.1 M, once with water, once with brine, was dried over Na2SO4, was filtered and was concentrated under reduced pressure to afford tert-butyl 4-(2-chloro-4-nitrophenyl)piperazine-l-carboxylate (2.50 mmol, 854 mg, 86%). The product was used without further purification. LC (Zorbax SB-Ci8, 3.5μm, 4.6x30mm Column): RT = 3.19 min; MS m/z ES+= 342.
References:
WO2009/10454,2009,A2 Location in patent:Page/Page column 36
350-30-1
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57260-71-6
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$5.00/5g
193902-80-6
13 suppliers
$24.05/250mg
29682-39-1
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$9.00/1g
57260-71-6
741 suppliers
$5.00/5g
193902-80-6
13 suppliers
$24.05/250mg
182618-86-6
114 suppliers
$9.00/1g
193902-80-6
13 suppliers
$24.05/250mg
41252-96-4
82 suppliers
$24.00/5g
193902-80-6
13 suppliers
$24.05/250mg