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18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
ChemicalBook CAS DataBase List 1-Boc-4-(3-broMopropyl)piperidine
164149-27-3

1-Boc-4-(3-broMopropyl)piperidine synthesis

3synthesis methods
TERT-BUTYL 4-(3-HYDROXYPROPYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE

156185-63-6
138 suppliers
$24.00/250mg

1-Boc-4-(3-broMopropyl)piperidine

164149-27-3
70 suppliers
$28.00/100mg

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Yield:164149-27-3 72%

Reaction Conditions:

with carbon tetrabromide;triphenylphosphine in tetrahydrofuran at 20; for 20 h;

Steps:

12
Compound 12; N-Boc-4-(3-bromopropyl)piperidine; N-Boc-4-(3-hydroxypropyl)piperidine (160 mg, 0.658 mmol) was dissolved in dry THF (5 mL ), and carbon tetrabromide (265 mg, 0.79 mmol) was added. Then a solution of triphenylphosphine (207 mg, 0.79 mmol) in dry tetrahydrofuran (2 mL ) was added dropwise over 2 h. The mixture was stirred at room temperature for 18 h, and then diluted with diethyl ether (5 mL). The reaction mixture was filtered, the filtrate concentrated under vacuum, and the resulting residue was purified by silica gel column chromatography (9:1 hexanerethyl acetate) to give 12 (143 mg, 72%) as an oil.

References:

IMMUNE CONTROL, INC. WO2008/27521, 2008, A1 Location in patent:Page/Page column 58-59

FullText

4-Pyridinepropanol

2629-72-3
148 suppliers
$10.00/1g

1-Boc-4-(3-broMopropyl)piperidine

164149-27-3
70 suppliers
$28.00/100mg

References
7037-49-2 Synthesis
piperidine-4-propanol

7037-49-2
141 suppliers
$19.00/250mg

1-Boc-4-(3-broMopropyl)piperidine

164149-27-3
70 suppliers
$28.00/100mg

References