1-Bromo-5-phenylnaphthalene synthesis
- Product Name:1-Bromo-5-phenylnaphthalene
- CAS Number:911836-38-9
- Molecular formula:C16H11Br
- Molecular Weight:283.16
7351-74-8
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Yield:911836-38-9 70%
Reaction Conditions:
with tetrakis(triphenylphosphine) palladium(0);potassium carbonate in tetrahydrofuran;water at 70; for 5 h;Inert atmosphere;
Steps:
2 Synthesis of Intermediate E
In an argon (Ar) atmosphere, THF / water (18.7 g of 1,5-dibromonaphthalene, 2.86 g of phenylboronic acid, 0.813 g of Pd (PPh3) 4, and 5.15 g of K2CO3 dissolved in a 1 L three-necked flask ( 360 mL of the mixed solution of 8: 2) was heated and stirred at 70 ° C. for 5 hours. After air cooling, dichloromethane was added to separate the organic layer, and the solvent was distilled off. After the obtained crude product was purified by silica gel chromatography (using hexane), 4.65 g (yield 70%) of Intermediate E as a pale yellow solid was obtained.
References:
JP2019/127487,2019,A Location in patent:Paragraph 0123; 0124; 0125; 0126
68449-30-9
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911836-37-8
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5328-76-7
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4766-33-0
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