1-CYCLOPROPYL-1-METHYLETHANOL synthesis
- Product Name:1-CYCLOPROPYL-1-METHYLETHANOL
- CAS Number:930-39-2
- Molecular formula:C6H12O
- Molecular Weight:100.16
765-43-5
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$10.00/1g
75-16-1
278 suppliers
$12.00/10ml
930-39-2
50 suppliers
$45.00/10mg
Yield:930-39-2 92%
Reaction Conditions:
in diethyl ether at 20;Reflux;
Steps:
1
To a solution of 1-cyclopropylethan-1-one (1.0 g, 11.2 mmol) in anhydrous Et2O (5 mL) was added a solution of MgMeBr (4.4 mL, 13.2 mmol) at a rate suitable to maintain gentle reflux of the solvent, to afford the expected alcoholate as a white precipitate. The reaction mixture was maintained refluxing for an additional 30 minutes, then stirred at RT overnight, and quenched with sat. NH4Cl solution (5 mL). The resulting mixture was extracted with Et2O (5 mL), and the combined organic layers were washed with brine (5 mL), dried over Na2SO4, and filtered. The filtrate was concentrated in vacuo to afford 2-cyclopropylpropan-2-ol as a pale yellow oil (1.1 g, 92%). 1H NMR (500 MHz, CDCl3) δ 1.18 (s, 6H), 0.97-0.94 (m, 1H), 0.39-0.30 (m, 4H).
References:
WO2017/176961,2017,A1 Location in patent:Paragraph 00228
917-64-6
147 suppliers
$45.00/10ml
765-43-5
420 suppliers
$10.00/1g
930-39-2
50 suppliers
$45.00/10mg
765-43-5
420 suppliers
$10.00/1g
917-54-4
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$52.10/25ml
930-39-2
50 suppliers
$45.00/10mg
4606-07-9
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$10.00/1g
74-88-4
357 suppliers
$15.00/10g
930-39-2
50 suppliers
$45.00/10mg
765-43-5
420 suppliers
$10.00/1g
676-58-4
295 suppliers
$15.00/25ml
930-39-2
50 suppliers
$45.00/10mg