1-CYCLOPROPYL-1-METHYLETHANOL synthesis
- Product Name:1-CYCLOPROPYL-1-METHYLETHANOL
- CAS Number:930-39-2
- Molecular formula:C6H12O
- Molecular Weight:100.16
765-43-5
412 suppliers
$10.00/1g
75-16-1
280 suppliers
$12.00/10ml
930-39-2
49 suppliers
$45.00/10mg
Yield:930-39-2 92%
Reaction Conditions:
in diethyl ether at 20;Reflux;
Steps:
1
To a solution of 1-cyclopropylethan-1-one (1.0 g, 11.2 mmol) in anhydrous Et2O (5 mL) was added a solution of MgMeBr (4.4 mL, 13.2 mmol) at a rate suitable to maintain gentle reflux of the solvent, to afford the expected alcoholate as a white precipitate. The reaction mixture was maintained refluxing for an additional 30 minutes, then stirred at RT overnight, and quenched with sat. NH4Cl solution (5 mL). The resulting mixture was extracted with Et2O (5 mL), and the combined organic layers were washed with brine (5 mL), dried over Na2SO4, and filtered. The filtrate was concentrated in vacuo to afford 2-cyclopropylpropan-2-ol as a pale yellow oil (1.1 g, 92%). 1H NMR (500 MHz, CDCl3) δ 1.18 (s, 6H), 0.97-0.94 (m, 1H), 0.39-0.30 (m, 4H).
References:
WO2017/176961,2017,A1 Location in patent:Paragraph 00228
917-64-6
149 suppliers
$45.00/10ml
765-43-5
412 suppliers
$10.00/1g
930-39-2
49 suppliers
$45.00/10mg
765-43-5
412 suppliers
$10.00/1g
917-54-4
185 suppliers
$52.10/25ml
930-39-2
49 suppliers
$45.00/10mg
4606-07-9
149 suppliers
$10.00/1g
74-88-4
359 suppliers
$15.00/10g
930-39-2
49 suppliers
$45.00/10mg
765-43-5
412 suppliers
$10.00/1g
676-58-4
293 suppliers
$15.00/25ml
930-39-2
49 suppliers
$45.00/10mg