1-Methyl-1,2,3,4-tetrahydroquinolin-4-aMine synthesis
- Product Name:1-Methyl-1,2,3,4-tetrahydroquinolin-4-aMine
- CAS Number:851390-46-0
- Molecular formula:C10H14N2
- Molecular Weight:162.23
1198-15-8
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851390-46-0
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Yield:851390-46-0 80%
Reaction Conditions:
with ammonium acetate;sodium cyanoborohydride in methanol at 70; for 5 h;
Steps:
42.2 Step 2
A mixture of compound 2 (1.5 g, 9.3 mnuol). NaBI-{3CN (1.8 g, 27.9 mmoi),and AcONH4 (3.6 g, 46.5 mnuol) in MeOH (30 in) was stirred at 70°C for 5h. To themixture was added EA (lOOmi) and aqueous saturated NaCi (100 in), and the resulting reaction mixture was stirred for 30 mm. The organic layer was separated. washed by aqueous saturated NaCI (50 nui*2), dried and concentrated to afford compound 3 (1.4 g, 80%) as a white solid.
References:
WO2016/94824,2016,A1 Location in patent:Page/Page column 80; 81
74668-57-8
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851390-46-0
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4295-36-7
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