ChemicalBook CAS DataBase List 1-Methyl-2-piperidinemethanol

1-Methyl-2-piperidinemethanol synthesis

6synthesis methods

Product Name:1-Methyl-2-piperidinemethanol
CAS Number:20845-34-5
Molecular formula:C7H15NO
Molecular Weight:129.2

98303-20-9 Synthesis

98303-20-9
240 suppliers
$11.19/5G

20845-34-5
205 suppliers
$9.00/5g

Yield:-

Reaction Conditions:

with LiAlH₄ in tetrahydrofuran;

Steps:

10 1-Methyl-2-piperidinemethanol

EXAMPLE 10 1-Methyl-2-piperidinemethanol The title compound of Example 9 (23.2 g, 101 mmol) in dry THF (100 mL) was added dropwise to a 1.0M solution of LiAlH₄ in THF (405 mL, 405 mmol, 4eq) and the reaction mixture was refluxed overnight and the product was isolated as described in Example 6 to give the product (13.1 g, quantative) as a colorless oil. The fumarate salt crystallized from 2-propanol: mp 118°-120° C.; ¹ H-NMR (CDCl₃) ⅆ3.85 (dd, J=gem=11 Hz, J=3.9 Hz, 1H), 3,39 (dd, J=gem=11 Hz, J=2.2 Hz, 1H), 2.89 (m, 1H), 2.30 (s, 3H), 2.15 (m, 1H), 1.97 (m, 1H), 1.76 (m, 1H), 1.42-1.68 (complex m, 4H), 1.28 (m, 1H); CIMS (MH⁺ calcd for C₇ H₁₅ NO): 130. Found (MH⁺): 130; Anal. (C₁₁ H₁₉ NO₅): C,H,N.