1-Methyl-4-(hydroxyethyl)piperidine synthesis
- Product Name:1-Methyl-4-(hydroxyethyl)piperidine
- CAS Number:21156-84-3
- Molecular formula:C8H17NO
- Molecular Weight:143.23
622-26-4
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Yield:-
Reaction Conditions:
Stage #1:4-(2-Hydroxyethyl)piperidine;formaldehyd with formic acid in water at 95; for 2 h;
Stage #2: with sodium hydrogencarbonate in water at 20;
Steps:
13 2-(1-Methylpiperidin-4-yl)ethyl 4-(4-methylphenyl)piperazine-1-carboxylate
Example 13 2-(1-Methylpiperidin-4-yl)ethyl 4-(4-methylphenyl)piperazine-1-carboxylate 2-Piperidin-4-yl-ethanol (2.37 g, 18.3 mmol) was dissolved in formic acid (2.1 mL, 55.7 mmol), 35% aqueous formaldehyde solution (4.5 mL, 55.4 mmol) and water (20 mL). The reaction mixture was heated at 95° C. for 2 hours, and then cooled to room temperature. The reaction mixture was quenched by slowly pouring it onto a saturated NaHCO3 solution (200 mL) and concentrated in vacuo. The residue was suspended in MeOH (100 mL) and stirred for 2 hours, filtered, and the filtrate was concentrated in vacuo to give 2-(1-methyl-piperidin-4-yl)-ethanol (3.38 g, 129%) as a colourless oil which was used without further purification. Analytical LCMS: (System C, RT=0.50 min), ES+: 144.1 [MH]+.
References:
Biovitrum AB US2009/281087, 2009, A1 Location in patent:Page/Page column 15
185942-85-2
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21156-84-3
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5344-27-4
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21156-84-3
62 suppliers
$60.00/100mg