ChemicalBook CAS DataBase List 1-NAPHTHOXYACETIC ACID

1-NAPHTHOXYACETIC ACID synthesis

9synthesis methods

Product Name:1-NAPHTHOXYACETIC ACID
CAS Number:2976-75-2
Molecular formula:C12H10O3
Molecular Weight:202.21

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2976-75-2
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Yield: 96%

Reaction Conditions:

with toluene-4-sulfonic acid in water at 51 - 153; under 3750.38 Torr; for 6 h;Autoclave;Temperature;

Steps:

8 Example 8
In the autoclave was added 21 ° C hot water 2160g,Methyl anthranilate 217.6 g (1 mol, content 99.3%),P-Toluenesulfonic acid 22.0g (content of 98%), naphthyl oxyacetic acid methyl ester, catalyst and water mass ratio of 1: 0.1: 10.Heated up to 0.5MPa (about 153 ° C ),Adjust the vent to maintain the reaction pressure, venting methanol vapor through the condenser to condense methanol aqueous solution. Pressure-keeping reaction for 6 hours.After the reaction was completed, the mixture was slowly vented and cooled to 50 ° C with stirring.Filtered while hot, 100g70-80 hot water wash the filter cake 3 times, dried to give the product 197.1g, purity 98.5%, yield 96%.

References:

Shandong Normal University;Chen Dongmei;Zhang Jine;Bi Yanying CN107311858, 2017, A Location in patent:Paragraph 0074-0092

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