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67852-27-1

1-Oxa-3-azaspiro[4.4]nonane-2,4-dione(6CI,9CI) synthesis

6synthesis methods
-

Yield:67852-27-1 77%

Reaction Conditions:

Stage #1: hydroxycyclopentanecarboxylic acid ethyl ester;Trichloroacetyl isocyanate in dichloromethane at 0 - 20;
Stage #2: with triethylamine in ethanol;Reflux;

References:

Li, Yue H.;Zhang, Li;Tseng, Pei-San;Zhang, Yongliang;Jin, Yu;Shen, Jingkang;Jin, Jian [Tetrahedron Letters,2009,vol. 50,# 7,p. 790 - 792] Location in patent:scheme or table