1-phenyl-9H-pyrido[3,4-b]indole-3-carboxylic acid synthesis
- Product Name:1-phenyl-9H-pyrido[3,4-b]indole-3-carboxylic acid
- CAS Number:374710-96-0
- Molecular formula:C18H12N2O2
- Molecular Weight:288.3
![9H-Pyrido[3,4-b]indole-3-carboxylic acid, 1-phenyl-, methyl ester](/CAS/20180529/GIF/81677-50-1.gif)
81677-50-1
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374710-96-0
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Yield:374710-96-0 93%
Reaction Conditions:
with water;sodium hydroxide in methanol; for 2 h;Reflux;
Steps:
4.2.4. Synthesis of 1-substituted-9H-pyrido[3,4-b]indole-3-carboxylic acid (5c-5o)
General procedure: To a solution of 4c-4o (0.5 mmol) in methanol (10 mL) wasadded 1 mol/l aqueous NaOH solution (10 mL), then the mixturewas stirred and heated at reflux for 2 h. After cooling to roomtemperature, the mixture was adjusted to pH 8 with 1 mol/l HClsolution. The precipitate was filtered off and the residue afford 5c-5o.
References:
Sheng, Tao;Kong, Mengmeng;Wang, Yujie;Wu, HuiJun;Gu, Qin;Chuang, Anita Shyying;Li, Shengkun;Gao, Xuewen [European Journal of Medicinal Chemistry,2021,vol. 222,art. no. 113563]
209169-30-2
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374710-96-0
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73-22-3
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100-52-7
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4299-70-1
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