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L-Tryptophan

Description Overview Content analysis Application References
L-Tryptophan
L-Tryptophan
CAS No.
73-22-3
Chemical Name:
L-Tryptophan
Synonyms
TRP;eh121;L-Trp;L-Ttp;EH 121;trofan;Lyphan;Eltrip;Tryptan;L-Trp-OH
CBNumber:
CB3750054
Molecular Formula:
C11H12N2O2
Formula Weight:
204.23
MOL File:
73-22-3.mol

L-Tryptophan Properties

Melting point:
289-290 °C (dec.)(lit.)
alpha 
-31.1 º (c=1, H20)
Density 
1.34
refractive index 
-32 ° (C=1, H2O)
storage temp. 
Store at RT.
solubility 
20% NH3: 0.1 g/mL at 20 °C, clear, colorless
form 
powder
pka
2.46(at 25℃)
color 
White to yellow-white
PH
5.5-7.0 (10g/l, H2O, 20℃)
Water Solubility 
11.4 g/L (25 ºC)
Merck 
14,9797
BRN 
86197
Stability:
Stable. Incompatible with strong acids, strong oxidizing agents.
CAS DataBase Reference
73-22-3(CAS DataBase Reference)
NIST Chemistry Reference
L-Tryptophan(73-22-3)
EPA Substance Registry System
L-Tryptophan(73-22-3)

SAFETY

Hazard Codes  Xi
Risk Statements  33-40-62-41-37/38-36/37/38-22
Safety Statements  24/25-36/37/39-36-26
WGK Germany  2
RTECS  YN6130000
8
TSCA  Yes
HS Code  29339990
Hazardous Substances Data 73-22-3(Hazardous Substances Data)

L-Tryptophan price More Price(31)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 51145 L-Tryptophan certified reference material, TraceCERT 73-22-3 100mg $89.6 2017-11-08 Buy
Sigma-Aldrich 1700501 L-Tryptophan United States Pharmacopeia (USP) Reference Standard 73-22-3 200mg $362.5 2017-11-08 Buy
TCI Chemical T0541 L-Tryptophan >98.5%(HPLC)(T) 73-22-3 25g $28 2017-12-01 Buy
TCI Chemical T0541 L-Tryptophan >98.5%(HPLC)(T) 73-22-3 100g $84 2017-12-01 Buy
Alfa Aesar A10230 L-Tryptophan, 99% 73-22-3 100g $117 2017-11-08 Buy

L-Tryptophan Chemical Properties,Uses,Production

Description

As an essential amino acid, L-Tryptophan is necessary for normal growth in infants and for nitrogen balance in adults, which cannot be synthesized from more basic substances in humans and other animals, suggesting that it is obtained only by intake of tryptophan or tryptophan-containing proteins for human body, which is particularly plentiful in chocolate, oats, milk, cottage cheese, red meat, eggs, fish, poultry, sesame, almonds, buckwheat, spirulina, and peanuts, etc. It can be used as a nutritional supplement for use as an antidepressant, anxiolytic, and sleep aid. Thus, L-Tryptophan can be used for depression, anxiety, sleep apnea, premenstrual syndrome and many other problems. Besides, it can also be used in managing pain tolerance and managing weight.
It works by increasing the levels of certain neurotransmitters in the brain called serotonin. People suffer from depression have an imbalance of serotonin and other brain chemicals. Thus, the increase of serotonin levels in the brain can improve symptoms of depression. L-Tryptopan serves as the precursor for the synthesis of serotonin, which is converted to serotonin in the body. As a result, the symptoms of depression and other problems are improved.

Overview

It is also known as α-aminoindolylpropionic acid. Appearance: white to slightly yellowish white crystal or crystalline powder. No smell; Slight bitter taste. Melting temperature: 289 ° C (decomposition); soluble in water. Applications: as food fortifier, antioxidant; also used in medicine. It is manufactured from indole aldehyde, alternatively also be synthesized from trypsin decomposition and synthesis.

Content analysis

Accurately weigh about 300 mg sample and dissolve it in 3ml formic acid and 50ml glacial acetic acid; add 2 drops crystal violet test solution (TS-250), titrate with 0.1mol / L perchloric acid to the green end point or until the blue color completely disappears. Each Ml of 0.1 mol / L perchloric acid corresponds to 20.42 mg of L-tryptophan (C11H12N2O2).

Application

Amino acids-type drug:
It can be used in amino acid infusion, being often combined with iron and vitamins. Its co-administration with VB6 can improve depression and prevention/treatment of skin disease; as a sleep sedative, it can be combined with L-dopa for the treatment of Parkinson's disease. It is carcinogenic to experimental animals; it may cause adverse reactions including nausea, anorexia and asthmas. Avoid combination with monoamine oxidase inhibitors.
Nutritional supplements:
Tryptophan contained in egg white protein, fish meat, corn meal and other amino acids are limited; content in cereals such as rice is also low. It can be combined with lysine, methionine and threonine for enhanced amino acids. It can be supplemented to corn product at the content of 0.02% tryptophan and 0.1% lysine, being capable of significantly improving the protein potency.

References

https://en.wikipedia.org/wiki/Tryptophan
http://www.medicinenet.com/tryptophan-oral_capsule_tablet/article.htm
http://bodyandhealth.canada.com/drug/getdrug/apo-tryptophan
https://www.drugbank.ca/drugs/DB00150

Chemical Properties

White to off-white crystalline powder

Chemical Properties

Appearance: white crystalline powder. Odorless, slightly bitter taste;
Solubility: slightly soluble in water (1.14%, 25 ℃), insoluble in ethanol; soluble in dilute acid or dilute alkali. mp 289 ° C (decomposition).
Isoelectric point: 5.89. [α] D + 2.8 (5 mol / L HCl), [α] D + 6.2 (0.5 mol / L NaOH).
It can be colored upon long-term exposure to light. Its co-heating reaction with water will generate a small amount of indole while heating in the presence of sodium hydroxide and copper sulfate will produce a large amount of indole. It is stable upon heating together with acid in the dark, but is easily to be decomposed when heated together with other amino acids, carbohydrates and aldehydes. L-tryptophan will be completely decomposed when applying acid to break down the protein.

Uses

adrenergic agonist

Definition

ChEBI: The L-enantiomer of tryptophan.

General Description

White powder with a flat taste. An essential amino acid; occurs in isomeric forms.

Air & Water Reactions

Slightly soluble in water.

Reactivity Profile

Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.

Health Hazard

ACUTE/CHRONIC HAZARDS: When heated to decomposition L-Tryptophan emits toxic fumes.

Fire Hazard

Flash point data for L-Tryptophan are not available. L-Tryptophan is probably combustible.

Toxicity

LD508mmol / kg (rat, intraperitoneal injection). It is safe when used in food (FDA, §172.320, 2000).

L-Tryptophan Preparation Products And Raw materials

Raw materials

Preparation Products


L-Tryptophan Suppliers

Global( 470)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shanghai Aladdin Bio-Chem Technology Co.,LTD 021-20337333/400-620-6333
021-50323701 sale@aladdin-e.com China 25121 65
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96820 76
PharmaBlock Sciences (Nanjing),Inc. 400 025 5188
86-025-86918232 sales_china@pharmablock.com China 6191 55
Meryer (Shanghai) Chemical Technology Co., Ltd. +86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-62670440(Beijing)
+86-(0)21-61259102(Shanghai) +86-(0)755-86170066(ShenZhen) +86-(0)10-88580358(Beijing) sh@meryer.com China 40398 62
INTATRADE GmbH +49 3493/605464
+49 3493/605470 sales@intatrade.de Germany 3588 66
Alfa Aesar 400-610-6006; 021-67582000
021-67582001/03/05 saleschina@alfa-asia.com China 30309 84
TAIYUAN RHF CO.,LTD. +86 351 7031519
+86 351 7031519 sales@RHFChem.com China 2362 56
TCI (Shanghai) Development Co., Ltd. 800-988-0390
021-67121385 sales@tcishanghai.com.cn China 22830 81
Beijing dtftchem Technology Co., Ltd. 13651141086; 86(10)60275028、60275820
86 (10) 60270825 dtftchem@sina.com China 3434 62
BeiJing Hwrk Chemicals Limted 4006990298;010-57411839;0757-86311057;021-51691807
010-87653215;0757-86311057;021-55236763 sales@hwrkchemical.com China 15553 55

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