ChemicalBook CAS DataBase List 1-Piperazinesulfonamide(7CI,8CI,9CI)

1-Piperazinesulfonamide(7CI,8CI,9CI) synthesis

4synthesis methods

Product Name:1-Piperazinesulfonamide(7CI,8CI,9CI)
CAS Number:5906-30-9
Molecular formula:C4H11N3O2S
Molecular Weight:165.21

1-Piperazinecarboxylic acid, 4-(aminosulfonyl)-, 1,1-dimethylethyl ester

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Yield:5906-30-9 100%

Reaction Conditions:

with trifluoroacetic acid in dichloromethane at 20; for 1 h;

Steps:

1 Deprotection of Boc (200 mg scale):

1 equivalent of compound A is added to a 100 ml round bottom flask and 10 ml of 20% trifluor acetic acid (TFA) in dichloromethane is added at RT and allowed to stir for 1 hour. The reaction mixture is evaporated. TLC medium: 9: 1 DCM and Methanol. Percentage of Yield: 100%. Data: mass spectra showed that deprotection was successful.

References:

WO2015/25283,2015,A2 Location in patent:Page/Page column 77