Welcome to chemicalbook!
Chinese English Japanese Germany Korea
400-158-6606
logo
Inquriy
Try our best to find the right business for you.
Messages
Do not miss inquiry messages Please log in to view all inquiry messages.
My chemicalbook

Welcome back!

Structured search
18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
ChemicalBook CAS DataBase List (1’R,2S)-2-(1’,2’-Dihydroxyethyl)-6-fluorochromane
303176-39-8

(1’R,2S)-2-(1’,2’-Dihydroxyethyl)-6-fluorochromane synthesis

8synthesis methods
2H-1-Benzopyran, 2-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]-6-fluoro-3,4-dihydro-, (2S)-

1030385-10-4
0 suppliers
inquiry

(1’R,2S)-2-(1’,2’-Dihydroxyethyl)-6-fluorochromane

303176-39-8
13 suppliers
$255.00/100mg

-

Yield:303176-39-8 43%

Reaction Conditions:

with water;acetic acid at 60 - 65; for 2.5 h;

Steps:

5

Diastereoisomeric mixture obtained in Example 3 was separated into the single diastereoisomers in accordance to known methods.(S)-6-fluoro-3,4-dihydro-2-((R)-2,2-dimethyl-l,3-dioxolan-4-yl)-2H-chromene (1.10 g, 4.4 mmol) was dissolved in acetic acid (9 ml) and demi water (3 ml). The reaction mixture was stirred vigorously and heated to 650C. After 2.5 h at 600C the reaction mixture was cooled to 25°C. The solution was then concentrated in vacuo to obtain a vetrous oil. Chromatographic separation on silica of the crude, using a mixture of heptane : ethyl acetate 1 : 1 as eluent, furnished 0.40 g of (R)-l-((S)-6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethane-l,2-diol as a white solid (43% yield). NMR: δH(400 MHz; CDCl3) 6.83-6.69 (3H, m, Ar), 4.05-3.98 (IH, m), 3.90-3.80 (3H, m), 2.91-2.74 (2H, m), 2.18-2.11 (IH, m), 1.91-1.81 (IH, m). Chiral HPLC: ee 94%.

References:

WO2008/64827,2008,A2 Location in patent:Page/Page column 28-29

Ethanone, 1-[(2S)-6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl]-2-hydroxy-

1421916-54-2
0 suppliers
inquiry

905454-57-1 Synthesis
(1’S,2S)-2-(1’,2’-Dihydroxyethyl)-6-fluorochromane

905454-57-1
13 suppliers
$140.00/50mg

(1’R,2S)-2-(1’,2’-Dihydroxyethyl)-6-fluorochromane

303176-39-8
13 suppliers
$255.00/100mg

References
797054-19-4 Synthesis
(1’R,2S)-2-[(1’,2’-O-Isopropylidene)dihydroxyethyl]-6-fluorochroman-4-one

797054-19-4
5 suppliers
$120.00/100mg

(1’R,2S)-2-(1’,2’-Dihydroxyethyl)-6-fluorochromane

303176-39-8
13 suppliers
$255.00/100mg

References
(+)-(S,R)-6-fluoro-3,4-dihydro-2-(2-oxiranyl)-2H-1-benzopyran

197706-51-7
30 suppliers
inquiry

(1’R,2S)-2-(1’,2’-Dihydroxyethyl)-6-fluorochromane

303176-39-8
13 suppliers
$255.00/100mg

References
2H-1-Benzopyran, 2-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]-6-fluoro-3,4-dihydro-

1030385-06-8
0 suppliers
inquiry

(1’R,2S)-2-(1’,2’-Dihydroxyethyl)-6-fluorochromane

303176-39-8
13 suppliers
$255.00/100mg

303176-45-6 Synthesis
(1’R,2R)-2-(1’,2’-Dihydroxyethyl)-6-fluorochromane

303176-45-6
14 suppliers
$140.00/100mg

303176-43-4 Synthesis
(1’S,2R)-2-(1’,2’-Dihydroxyethyl)-6-fluorochromane

303176-43-4
14 suppliers
$140.00/50mg

References