(4-METHYL-PIPERAZIN-1-YL)-(S)-PYRROLIDIN-2-YL-METHANONE synthesis
- Product Name:(4-METHYL-PIPERAZIN-1-YL)-(S)-PYRROLIDIN-2-YL-METHANONE
- CAS Number:100158-68-7
- Molecular formula:C10H19N3O
- Molecular Weight:197.28
![1-Pyrrolidinecarboxylic acid, 2-[(4-methyl-1-piperazinyl)carbonyl]-, phenylmethyl ester, (S)- (9CI)](/CAS/20210305/GIF/100158-67-6.gif)
100158-67-6
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100158-68-7
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Yield:100158-68-7 90%
Reaction Conditions:
with palladium on activated charcoal;hydrogen in methanol at 20; under 760.051 Torr; for 24 h;
Steps:
29.2 Step 2
[0173] To a 500 ml three-necked flask, 2215-151a-1 (1.66 g, 5 mmol), palladium on carbon (0.16 g), and methanol (25 mE) were added, and hydrogen gas was introduced. The mixture was stirred at room temperature under normal pressure for 24 hours. The palladium on carbon was removed by filtration, and the filtrate was subjected to rotary evaporation under reduced pressure. The resulting oil was separated by silica gel chromatography column to obtain 0.89 g of 2215-151a-2 in 90% yield.
References:
US2017/267718,2017,A1 Location in patent:Paragraph 0172; 0173
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100158-68-7
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