3-(DIMETHYLAMINO)-1-PHENYL-2-(PHENYLSULFONYL)-2-PROPEN-1-ONE synthesis
- Product Name:3-(DIMETHYLAMINO)-1-PHENYL-2-(PHENYLSULFONYL)-2-PROPEN-1-ONE
- CAS Number:108289-88-9
- Molecular formula:C17H17NO3S
- Molecular Weight:315.39
Yield:-
Reaction Conditions:
in 5,5-dimethyl-1,3-cyclohexadiene; for 15 h;Reflux;
Steps:
Synthesis of 1-benzenesulfonyl-1-benzoyl-2-(N,N-dimethylamino)ethane derivatives 14a-c
General procedure: To hot solution of 1-phenyl-2-(phenylsulfonyl)ethan-1-one derivatives 4a-d (12.5 mmol) indry xylene, equivalent amount of DMFDMA was added. The reaction mixture was heated under reflux for 15 h, the poured onto petroleum ether (50 mL). The formed solid was collected byfiltration and recrystallized from methanol to furnish the final compounds 14a-c
References:
Eldeeb, Assem H.;Abo-Ashour, Mahmoud F.;Angeli, Andrea;Bonardi, Alessandro;Lasheen, Deena S.;Elrazaz, Eman Z.;Nocentini, Alessio;Gratteri, Paola;Abdel-Aziz, Hatem A.;Supuran, Claudiu T. [European Journal of Medicinal Chemistry,2021,vol. 221,art. no. 113486] Location in patent:supporting information
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