(S)-Benzyl (1-(Methoxy(Methyl)Amino)-4-Methyl-1-Oxopentan-2-Yl)Carbamate synthesis
- Product Name:(S)-Benzyl (1-(Methoxy(Methyl)Amino)-4-Methyl-1-Oxopentan-2-Yl)Carbamate
- CAS Number:109075-73-2
- Molecular formula:C16H24N2O4
- Molecular Weight:308.37
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Yield:-
Steps:
R.21 N-Benzyloxycarbonyl-L-leucine (N-methyl-N-methoxy)amide
Referential Example 21 N-Benzyloxycarbonyl-L-leucine (N-methyl-N-methoxy)amide Following the procedure described in Referential Example 1, but using N-benzyloxycarbonyl-L-leucine (2.45 g) as a starting material, the desired compound was obtained (2.61 g). NMR spectrum (270 MHz, CDCl3) δ ppm: 0.93 (3H, d, J=6.6 Hz), 0.97 (3H, d, J=6.6 Hz), 1.47 (2H, t, J=6.6 Hz), 1.72 (1H, m), 3.20 (3H, s), 3.79 (3H, s), 4.79 (1H, m), 5.06 (1H, d, J=12.5 Hz), 5.12 (1H, d, J=12.5 Hz), 5.37 (1H, d, J=9.2 Hz), 7.23-7.41 (5H, complex) IR absorption spectrum (liquid film) cm-1: 3306 (m), 2958 (m), 1720 (s), 1660 (s) High resolution MS spectrum [M]+ =308.1742 (C16 H24 N2 O4); Calcd. value: 308.1736 [α]D26 =-8.4° (c=1.01, CHCl3)
References:
Sankyo Company, Limited US5643908, 1997, A
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