ChemicalBook
Chinese Japanese Germany

L-Leucine

description Chemical Properties Uses toxicity
L-Leucine
L-Leucine
CAS No.
61-90-5
Chemical Name:
L-Leucine
Synonyms
LEU;L-LEU;Leucin;LEUCINE;CH79091;H-LEU-OH;L-Leu-OH;1-Leucine;L-LEUCINE;FEMA 3297
CBNumber:
CB8742186
Molecular Formula:
C6H13NO2
Formula Weight:
131.17
MOL File:
61-90-5.mol

L-Leucine Properties

Melting point:
>300 °C(lit.)
alpha 
15.4 º (c=4, 6N HCl)
Density 
1,293 g/cm3
vapor pressure 
<1 hPa (20 °C)
FEMA 
3297 | L-LEUCINE
refractive index 
1.4630 (estimate)
Flash point:
145-148°C
storage temp. 
Store at RT.
solubility 
1 M HCl: 50 mg/mL
form 
powder
pka
2.328(at 25℃)
color 
White to Off-white
PH
5.5-6.5 (20g/l, H2O, 20℃)
optical activity
[α]20/D +15.5°, c = 2 in 6 M HCl
Water Solubility 
22.4 g/L (20 C)
λmax
λ: 260 nm Amax: 0.05
λ: 280 nm Amax: 0.05
Sublimation 
145-148 ºC
Merck 
14,5451
BRN 
1721722
Stability:
Stability Moisture and light sensitive. Incompatible with strong oxidising agents.
CAS DataBase Reference
61-90-5(CAS DataBase Reference)
NIST Chemistry Reference
Leucine(61-90-5)
EPA Substance Registry System
L-Leucine(61-90-5)

SAFETY

Safety Statements  24/25
WGK Germany  3
RTECS  OH2850000
TSCA  Yes
HS Code  29224995

L-Leucine price More Price(34)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 61819 L-Leucine BioUltra, ≥99.5% (NT) 61-90-5 25g $56.1 2018-11-13 Buy
Sigma-Aldrich 1357001 L-Leucine United States Pharmacopeia (USP) Reference Standard 61-90-5 200mg $414.05 2018-11-13 Buy
Alfa Aesar A12311 L-Leucine, 99% 61-90-5 100g $44.6 2018-11-13 Buy
Alfa Aesar A12311 L-Leucine, 99% 61-90-5 500g $153 2018-11-13 Buy
Sigma-Aldrich L8000 L-Leucine reagent grade, ≥98% (HPLC) 61-90-5 250g $158 2018-11-13 Buy

L-Leucine Chemical Properties,Uses,Production

description

L-leucine is one of the eight essential amino acids, and belonging to the aliphatic amino acids within twenty kinds of proteins. L-leucine and L-isoleucine and L-valine are called three branched chain amino acids. L-leucineLeucine and D-leucine are enantiomers . It is a white shiny hexahedral crystal or white crystalline powder at room temperature , Odorless, slightly bitter . In the presence of hydrocarbons ,it is stable in the aqueous mineral acid. Per gram is dissolved in 40ml water and about 100ml acetic acid. Very slightly soluble in ethanol or ether, dissolved in formic acid, dilute hydrochloric acid, a solution of alkali hydroxides and a solution of carbonates.
L-leucine can promote insulin secretion, can lower blood sugar; promote sleep, reduce sensitivity to pain, migraine headaches, anxiety and ease tension, reduce symptoms of chemical reactions disorder in the body caused by alcohol , and helps control alcoholism; it has a role in the treatment of dizziness , also can promote skin wound and bone healing, so doctors usually advise patients to take leucine supplements after surgery. amino acid infusion and comprehensive amino acid preparations are often formulated to be used in the treatment or health care; also be used as food, cosmetics and feed additives and plant growth promoter.
The best food sources of leucine include brown rice, beans, meat, nuts, soy flour, and whole wheat. Excessive intake can also cause side effects, high intake can cause pellagra, vitamin A deficiency, dermatitis, diarrhea, mental disorders and other issues,which needs to be paid attention to . Diet containing too much leucine will increase the number of ammonia in the body and destroy the liver and kidney function. Therefore, patients with impaired liver or kidney function should not be excessive intake, otherwise it will exacerbate the condition.

Chemical Properties

White shiny hexahedral crystals or white crystalline powder. Slightly bitter (DL-leucine is sweet). Sublimation at 145~148 ℃. Melting point 293~295 ℃ (decomposition). It belongs to the essential amino acids,and adult men requirement is 2.2g/d (151 version). It is necessary in normal growth for infants and maintaining normal nitrogen balance for adults.
Natural products are found in the spleen, heart, etc., and are present in a variety of plant and animal tissues in the form of the proteins, free out after decomposition and corruption.

Uses

Amino acid drugs. Used as amino acid infusion and comprehensive amino acid preparations. For the diagnosis and treatment of children with idiopathic high blood sugar and glucose metabolism disorders,bile liver disease associated with reduced secretion , anemia, poisoning, muscular dystrophy, poliomyelitis, neuritis and mental illness. Diabetes, cerebral vascular sclerosis and kidney disease associated with proteinuria and hematuria is contraindicated. Gastric and duodenal ulcer patients should not be served.
The product is used as a nutritional supplement,an amino acid infusion preparation and a comprehensive amino acid preparation,a hypoglycemic agent, a plant growth promoter.The product can be used as a spice according to GB 2760-8 .

toxicity

Safe for food (FDA, §172.3202000).
LD505379mg/kg (rat, subcutaneously).

Chemical Properties

White crystalline powder

Chemical Properties

Leucine occurs as a white or almost off-white crystalline powder or shiny flakes.

Uses

Amino acid.

Production Methods

Leucine is produced microbially by incubating an amino-acidproducing microorganism including but not exclusive to Pseudomonas, Escherichia, Bacillus, or Staphylococcus in the presence of oxygen and a hydrocarbon. The nutrient medium should contain an inhibitory amount of a growth inhibitor that is a chemically similar derivative of leucine (e.g. methylallylglycine, a-hydrozinoisocaproic acid, or b-cyclopentanealanine) to inhibit the growth of the organism except for at least one mutant that is resistant to the inhibitory effect. The resistant mutant is then isolated and grown in the presence of oxygen and the hydrocarbon in the absence of the inhibitor. The mutant cells are then harvested and a nutrient medium is formed that includes a hydrocarbon as the sole source of carbon. Finally, the harvested cells are incubated in the medium in the presence of oxygen.

Definition

ChEBI: The L-enantiomer of leucine.

Pharmaceutical Applications

Leucine is used in pharmaceutical formulations as a flavoring agent. It has been used experimentally as an antiadherent to improve the deagglomeration of disodium cromoglycate micro-particles and other compounds in inhalation preparations; and as a tablet lubricant. Leucine copolymers have been shown to successfully produce stable drug nanocrystals in water.

Safety

Leucine is an essential amino acid and is consumed as part of a normal diet. It is generally regarded as a nontoxic and nonirritant material. It is moderately toxic by the subcutaneous route.
LD50 (rat, IP): 5.379 g/kg

storage

Leucine is sensitive to light and moisture, and should be stored in an airtight container in a cool, dark, dry place.

Purification Methods

Likely impurities are isoleucine, valine, and methionine. Crystallise L-leucine from water by adding 4 volumes of EtOH. It sublimes at 180-188o/0.3mm with 99.1% recovery, and unracemised [Gross & Gradsky J Am Chem Soc 77 1678 1955]. [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 p 2075-2094 1961, Kameda et al. J Pharm Soc Jpn 78 763 1958, Beilstein 4 IV 2738.]

Incompatibilities

Leucine is incompatible with strong oxidizing agents.

Regulatory Status

Included in the FDA Inactive Ingredients Database (IV infusion; oral tablets). Included in nonparenteral medicines licensed in the UK.

L-Leucine Preparation Products And Raw materials

Raw materials

Preparation Products


L-Leucine Suppliers

Global( 498)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 sales@capotchem.com China 19953 60
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3217 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 22049 58
Shanghai Bojing Chemical Co.,Ltd.
+86-21-37122233
+86-21-37127788 Candy@bj-chem.com CHINA 500 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20786 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32651 55
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 E-mail:sales03@shyrchem.com
+86-21-34979012 sales03@shyrchem.com CHINA 663 60
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 14293 60
QUALITY CONTROL CHEMICALS INC.
13606120588
orders@qcchemical.com CHINA 8430 58
Hubei Jusheng Technology Co.,Ltd.
86-155-27864001
peter@hubeijusheng.com CHINA 18004 58

View Lastest Price from L-Leucine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-07-30 L-Leucine
61-90-5
US $100.00 / KG 1KG 99% Customized career henan chemical co

L-Leucine Spectrum


61-90-5(L-Leucine)Related Search:


  • (s)-2-amino-4-methylvalericacid
  • 1-Leucine
  • 2-Amino-4-methylpentanoic acid
  • 2-amino-4-methylpentanoicacid
  • 2-amino-4-methyl-valericaci
  • 4-methyl-l-norvalin
  • 4-methyl-norvalin
  • alpha-Amino-gamma-methylvaleric acid
  • alpha-amino-gamma-methylvalericacid
  • iso-C4H9CH(NH2)COOH
  • (S)-(+)-LEUCINE
  • (S)-2-AMINO-4-METHYLPENTANOIC ACID
  • RARECHEM AB PP 3754
  • L-A-AMINOISOCAPROIC ACID
  • L-A-AMINO-G-METHYL VALERIC ACID
  • L-2-AMINO-4-METHYLPENTANOIC ACID
  • L-2-AMINO-4-METHYLVALERIC ACID
  • L-LEU
  • L-(-)-LEUCINE
  • L-LEUCINE
  • LEUCINE, L-
  • LEU
  • LEUCINE
  • FEMA 3297
  • H-L-LEU-OH
  • H-LEU-OH
  • L-Leucine 99+ %
  • L-α-Aminoisocaproic acid
  • L(-)-Leucin
  • l-alpha-aminoisocaproicacid
  • Leucin
  • L-α-Amino-isocapronsαure
  • Norvaline, 4-methyl-
  • Pentanoic acid, 2-amino-4-methyl-
  • Pentanoic acid, 2-amino-4-methyl-, (S)-
  • pentanoicacid,2-amino-4-methyl-,(S)-
  • Valeric acid, 2-amino-4-methyl-
  • α-amino-γ-methylvalericacid
  • L-Leucine USP24
  • L-LEUCINE SIGMAULTRA
  • L-LEUCINE SOLUTION INSECT CELL CULTURE*T ESTED
  • L-Leucine, 99% (97+% EE/GLC)
  • L-LEUCINE, PH EUR
  • L-LEUCINE 98.5+% FCC
  • L-Leucine USP, Amino
  • H-Leu-OH (L-Leucine)
  • L-LEUCINERESEARCH GRADE
  • L-Leucine,(S)-2-Amino-4-methylpentanoic acid, Leucinum
  • L-Leucine,(S)-2-Amino-4-methylpentanoic acid
  • L-Leucine, extra pure, Ph Eur, USP, BP
  • L-Leucine (200 mg)
  • L-α-AMinoisobutylacetic acid
  • EMPROVE(R) L-Leucine, USP, Ph Eur
  • L-Leucine, FCC
  • L-Leucine, 99% 100GR
  • (S)-(+)-LEUCINE FOR SYNTHESIS
  • Leucine Solution (L)
  • L-Leucine, Leu
Copyright 2017 © ChemicalBook. All rights reserved