Methyl 4-Oxo-4,5,6,7-Tetrahydrobenzo[B]Thiophene-5-Carboxylate synthesis
- Product Name:Methyl 4-Oxo-4,5,6,7-Tetrahydrobenzo[B]Thiophene-5-Carboxylate
- CAS Number:112101-60-7
- Molecular formula:C10H10O3S
- Molecular Weight:210.25
13414-95-4
140 suppliers
$25.00/1g
616-38-6
718 suppliers
$5.00/5G
112101-60-7
12 suppliers
$65.00/5mg
Yield:112101-60-7 125 mg
Reaction Conditions:
with sodium hydroxide at 85; for 3 h;Inert atmosphere;
Steps:
11a a) Methyl 4-oxo-4,5,6,7-tetrahydrobenzothiophene-5-carboxylate
Under nitrogen protection, 6,7-dihydrobenzothiophen-4(5H)-one (110 mg)Dissolved in dimethyl carbonate (5ml),Sodium hydrogen (35 mg, 60% w/w) was added in portions with stirring,The reaction was refluxed at 85°C for 3 hours. It was then cooled to 10°C, quenched by adding water (20 ml), and extracted by adding ethyl acetate (50 ml). The organic phase was concentrated to dryness, and the residue was subjected to silica gel column chromatography to obtain 125 mg of the title product.
References:
CN114380841,2022,A Location in patent:Paragraph 0171-0174
13414-95-4
140 suppliers
$25.00/1g
112101-60-7
12 suppliers
$65.00/5mg
13414-95-4
140 suppliers
$25.00/1g
17640-15-2
61 suppliers
$85.00/250mg
112101-60-7
12 suppliers
$65.00/5mg