Carbamic acid, N-[[[(1,1-dimethylethoxy)carbonyl]amino]-1H-pyrazol-1-ylmethylene]-, 1,1-dimethylethyl ester, [N(Z)]- synthesis
- Product Name:Carbamic acid, N-[[[(1,1-dimethylethoxy)carbonyl]amino]-1H-pyrazol-1-ylmethylene]-, 1,1-dimethylethyl ester, [N(Z)]-
- CAS Number:1143572-00-2
- Molecular formula:C14H22N4O4
- Molecular Weight:310.35
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Yield:1143572-00-2 98%
Reaction Conditions:
Stage #1: tert-butyl (amino(1H-pyrazol-1-yl)methylene)carbamatewith sodium hydride in tetrahydrofuran;mineral oil at 0; for 0.5 h;Inert atmosphere;Schlenk technique;
Stage #2: di-tert-butyl dicarbonate in tetrahydrofuran;mineral oil at 25; for 2 h;Inert atmosphere;Schlenk technique;
References:
Dolbois, Aymeric;Batiste, Laurent;Wiedmer, Lars;Dong, Jing;Brütsch, Manuela;Huang, Danzhi;Deerain, Nicholas M.;Spiliotopoulos, Dimitrios;Cheng-Sánchez, Iván;Laul, Eleen;Nevado, Cristina;?led?, Pawe?;Caflisch, Amedeo [ACS Medicinal Chemistry Letters,2020,vol. 11,# 8,p. 1573 - 1580] Location in patent:supporting information
24424-99-5
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152120-61-1
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24424-99-5
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4023-02-3
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152120-61-1
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1143572-00-2
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24424-99-5
862 suppliers
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4023-02-3
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1143572-00-2
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