tert-butyl 5-tosyl-5H-pyrrolo[2,3-b]pyrazin-2-ylcarbamate synthesis
- Product Name:tert-butyl 5-tosyl-5H-pyrrolo[2,3-b]pyrazin-2-ylcarbamate
- CAS Number:1201187-44-1
- Molecular formula:C18H20N4O4S
- Molecular Weight:388.44
4248-19-5
384 suppliers
$5.00/5g
1201186-54-0
181 suppliers
$41.00/100mg
1201187-44-1
231 suppliers
$220.00/250mg
Yield:1201187-44-1 75%
Reaction Conditions:
with palladium diacetate;potassium carbonate;4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene in 1,4-dioxane at 105; for 2.5 h;
Steps:
56.3 Step 3: tert-butyl (5-tosyl-5H-pyrrolo[2,3-b]pyrazin-2-yl)carbamate
To a solution of 2-bromo-5-tosyl-5H-pyrrolo[2,3-b]pyrazine (624 mg, 1.77 mmol) in1,4-dioxane (10 mL) were added tert-butyl carbamate (311 mg, 2.65 mmol), potassium carbonate(734 mg, 5.31 mmol), xantphos (209 mg, 0.35 mmol) and palladium acetate (41 mg, 0.17 mmol).The mixture was heated to 105 oc and stirred for 2.5 h. The reaction mixture was concentrated invacuo and the residue was purified by silica gel column chromatography (PE/EtOAc (v/v) = 1011)to give the title compound as a white solid (513 mg, 75 %).
References:
SUNSHINE LAKE PHARMA CO., LTD.;TANG, Changhua;REN, Qingyun;YIN, Junjun;YI, Kai;LEI, Yibo;WANG, Yejun;ZHANG, Yingjun WO2018/108125, 2018, A1 Location in patent:Paragraph 00588
875781-41-2
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$20.00/100mg
1201187-44-1
231 suppliers
$220.00/250mg
875781-43-4
279 suppliers
$19.00/1g
1201187-44-1
231 suppliers
$220.00/250mg
98-59-9
626 suppliers
$9.00/5g
1201187-44-1
231 suppliers
$220.00/250mg
1201186-54-0
181 suppliers
$41.00/100mg
1201187-44-1
231 suppliers
$220.00/250mg