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18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
ChemicalBook CAS DataBase List (R)-3-AMino-4-(2,4,5-trifluoro-phenyl)-butyric acid hydrochloride
1204818-19-8

(R)-3-AMino-4-(2,4,5-trifluoro-phenyl)-butyric acid hydrochloride synthesis

12synthesis methods
486460-00-8 Synthesis
Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid

486460-00-8
355 suppliers
$14.00/5g

(R)-3-AMino-4-(2,4,5-trifluoro-phenyl)-butyric acid hydrochloride

1204818-19-8
84 suppliers
$28.00/100mg

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Yield: 82.8%

Reaction Conditions:

with hydrogenchloride in ethyl acetate at 20; for 4 h;

Steps:

7
Example 7 1.0 g (3.0 mmol) of R-beta-t-butoxyl carbonyl amino-2,4,5-trifluorophenylbutyric acid (Ic) was added to 20 mL of the mixture of ethyl acetate and HCl (2 M). The mixture was stirred for 4 hours at room temperature. The solution was concentrated to half its volume at low temperature, and crystals precipitated from the solution. The resulting precipitates were collected by filtration and dried to obtain 0.67 g of R-beta-amino-2,4,5-trifluorophenylbutyric acid hydrochloride salt (Ia). Melting point: 204.5-207.5° C. [a]D25=-6.8° (C=0.8, methanol). Yield: 82.8%.

References:

Jiangsu Hengrui Medicine Co., Ltd. US2011/130587, 2011, A1 Location in patent:Page/Page column 5

(R)-Ethyl 2,4,5-trifluoro-b-homophenylalaninateHCl

1151240-91-3
21 suppliers
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(R)-3-AMino-4-(2,4,5-trifluoro-phenyl)-butyric acid hydrochloride

1204818-19-8
84 suppliers
$28.00/100mg

References
Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

1000210-73-0
0 suppliers
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(R)-3-AMino-4-(2,4,5-trifluoro-phenyl)-butyric acid hydrochloride

1204818-19-8
84 suppliers
$28.00/100mg

References
936630-57-8 Synthesis
(R)-3-Amino-4-(2,4,5-trifluorophenyl)butyric acid

936630-57-8
140 suppliers
$75.00/1G

(R)-3-AMino-4-(2,4,5-trifluoro-phenyl)-butyric acid hydrochloride

1204818-19-8
84 suppliers
$28.00/100mg

References
(R)-methyl 3-acetamido-4-(2,4,5-trifluorophenyl)butanoate

1234321-83-5
27 suppliers
inquiry

(R)-3-AMino-4-(2,4,5-trifluoro-phenyl)-butyric acid hydrochloride

1204818-19-8
84 suppliers
$28.00/100mg

References

(R)-3-AMino-4-(2,4,5-trifluoro-phenyl)-butyric acid hydrochloride Related Search:

2-CHLOROMETHYL-5-TRIFLUOROMETHYL-[1,3,4]OXADIAZOLE 2-Pentafluorophenyl-malonic acid diethyl ester 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride Sitagliptin Defuoro IMpurity 3 Sitagliptin N-Boc IMpurity 2,4,5-Trifluorophenylacetic acid 3,4-Difluorophenylacetic acid 2,4,5-Trifluorobenzaldehyde Ethyl trifluoroacetate 2,4-Difluorophenylacetic acid