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18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
ChemicalBook CAS DataBase List 2-Butyl-4-chloro-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxaldehyde
120568-18-5

2-Butyl-4-chloro-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxaldehyde synthesis

7synthesis methods
1H-Imidazole-5-carboxaldehyde, 2-butyl-4-chloro-1-[[4-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)phenyl]methyl]-

894806-33-8
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5-(2-Bromophenyl)-1-(triphenylmethyl)-1H-tetrazole

143945-72-6
43 suppliers
$75.00/50mg

2-Butyl-4-chloro-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxaldehyde

120568-18-5
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Yield:120568-18-5 65%

Reaction Conditions:

with potassium phosphate;(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in tetrahydrofuran; for 72 h;Product distribution / selectivity;Heating / reflux;

Steps:

9 Example 9

A Schlenk tube was charged with 2-n-butyl-4-chloro-1-[4-(5,5-dimethyl-[1,3,2]dioxaborinan-2-yl)benzyl)-1H-imidazole-5-carbaldehyde (190 mg), 5-(2-bromophenyl)-1-triphenylmethyl-1H-tetrazole (229 mg), anhydrous K3PO4 (317 mg) and anhydrous tetrahydrofuran (5 mL). The suspension was purged and degassed. Dichloro[1,1-bis(diphenylphosphino)ferrocene]palladium (II) (PdCl2(dppf)) (13 mg) was added, the mixture was purged and degassed. The reaction was refluxed for 72 h. After cooling to room temperature, the reaction mixture was filtered, the cake was washed with dichloromethane. The filtrate and washings were combined and evaporated to dryness. The residue was purified by column chromatography (eluant: cyclohexane/ethyl acetate, 9:1) to yield 212 mg (65%).

References:

EP1833801,2008,B1 Location in patent:Page/Page column 13

83857-96-9 Synthesis
2-Butyl-4-chloro-5-formylimidazole

83857-96-9
514 suppliers
$8.00/10g

124750-51-2 Synthesis
5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole

124750-51-2
465 suppliers
$6.00/1g

2-Butyl-4-chloro-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxaldehyde

120568-18-5
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References
Boronic acid, B-[4-[(2-butyl-4-chloro-5-formyl-1H-imidazol-1-yl)methyl]phenyl]-

894806-32-7
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5-(2-Bromophenyl)-1-(triphenylmethyl)-1H-tetrazole

143945-72-6
43 suppliers
$75.00/50mg

2-Butyl-4-chloro-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxaldehyde

120568-18-5
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References
2-Butyl-4-chloro-5-hydroxymethyl-1-[[2'-(1H-2-triphenylmethyl-tetrazol-5-yl)biphenyl-4-yl]methyl]imidazole

124751-00-4
48 suppliers
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2-Butyl-4-chloro-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxaldehyde

120568-18-5
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References
1H-Imidazole-5-carboxaldehyde, 2-butyl-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-

905456-95-3
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2-Butyl-4-chloro-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxaldehyde

120568-18-5
17 suppliers
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References