2-Propanesulfinamide, N-(4-chlorobutylidene)-2-methyl-, [N(E),S(S)]- synthesis

Yield:1207729-64-3 193 g

Reaction Conditions:

with copper(II) sulphate in toluene at 80; for 10 h;Solvent;

Steps:

1-2; 4

Dissolve 100g of 4-chlorobutyraldehyde in 500ml of toluene, add 125g of S-tert-butylsulfinamide and 150g of anhydrous copper sulfate after stirring; heat to 80°C for 10h reaction, the first mixture was obtained; the first mixture was cooled to room temperature, the filtrate was collected by filtration, and the filtrate was washed with 100 ml of clear water, repeated 3 times, after layering, the organic layer was dried with anhydrous sodium sulfate, filtered, and concentrated under reduced pressure at 50° C. until no more distillation was obtained to obtain 193 g of intermediate product I, namely (S,E)-N-(4-chlorobutenyl)-2-methyl-2-propanesulfinamide.

References:

CN114437029,2022,A Location in patent:Paragraph 0056; 0060; 0062-0063