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(S)-(-)-2-Methyl-2-propanesulfinamide

CAS No.
343338-28-3
Chemical Name:
(S)-(-)-2-Methyl-2-propanesulfinamide
Synonyms
(S)-2-METHYLPROPANE-2-SULFINAMIDE;TERT-BUTYL SULFINAMIDE;(S)-(-)-T-BUTYLSULFINAMIDE;S-BSN;finamide;Suprabasin;S-tert-butylsulfonamide;S- tert butyl sulfenaMide;Brilanestrant Impurity 10;(S)-(-)-TERT-BUTYLSULFINAMIDE
CBNumber:
CB0209955
Molecular Formula:
C4H11NOS
Molecular Weight:
121.2
MDL Number:
MFCD05861480
MOL File:
343338-28-3.mol
MSDS File:
SDS
Last updated:2023-12-11 16:06:43

(S)-(-)-2-Methyl-2-propanesulfinamide Properties

Melting point 97-101 °C(lit.)
alpha -4.5 º (c=1, CHCl3)
Boiling point 220.0±23.0 °C(Predicted)
Density 1.124
storage temp. 2-8°C
solubility Chloroform (Slightly), Methanol (Slightly)
pka 10.11±0.50(Predicted)
form Crystalline Powder
color White
optical activity [α]20/D 4.5°, c = 1 in chloroform
Stability store cold
InChI InChI=1/C4H11NOS/c1-4(2,3)7(5)6/h5H2,1-3H3/t7-/s3
InChIKey CESUXLKAADQNTB-SSDOTTSWSA-N
SMILES CC(C)([S@@](N)=O)C |&1:3,r|
CAS DataBase Reference 343338-28-3(CAS DataBase Reference)
FDA UNII I85YC2ZA8O

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280-P305+P351+P338-P304+P340-P405-P501A
Hazard Codes  Xi,Xn,F
Risk Statements  11-19-36/37-40
Safety Statements  16-26-36/37-24/25
WGK Germany  3
Hazard Note  Irritant/Keep Cold
TSCA  No
HS Code  29309090
NFPA 704
1
1 0

(S)-(-)-2-Methyl-2-propanesulfinamide price More Price(52)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 513210 (S)-(?)-2-Methyl-2-propanesulfinamide 97% 343338-28-3 1g $50.82 2024-03-01 Buy
Sigma-Aldrich 513210 (S)-(?)-2-Methyl-2-propanesulfinamide 97% 343338-28-3 5g $228 2024-03-01 Buy
TCI Chemical B2908 (S)-(-)-tert-Butylsulfinamide >98.0%(GC) 343338-28-3 1g $50 2024-03-01 Buy
TCI Chemical B2908 (S)-(-)-tert-Butylsulfinamide >98.0%(GC) 343338-28-3 5g $175 2024-03-01 Buy
Alfa Aesar H27115 (S)-(-)-2-Methyl-2-propanesulfinamide, 97% 343338-28-3 1g $76.65 2024-03-01 Buy
Product number Packaging Price Buy
513210 1g $50.82 Buy
513210 5g $228 Buy
B2908 1g $50 Buy
B2908 5g $175 Buy
H27115 1g $76.65 Buy

(S)-(-)-2-Methyl-2-propanesulfinamide Chemical Properties,Uses,Production

Description

Acid labile protecting groups are important in organic synthesis. The tert‐butyl group is commonly used for protection of a large variety of functional groups, e.g., acids, alcohols, phenols, and sulfonamides. Among them, s-tert-butyl sulfonamide is a chiral ligand used in pharmaceutical compositions. P, n-sulfoxide imine ligands were synthesized by condensation of s-tert-butylsulfonamide with aldehydes and ketones, and they can be used for asymmetric hydrogenation of olefins under iridium catalysis.

Physical properties

white to light yellow crystal powder

Uses

(S)-(-)-2-Methyl-2-propanesulfinamide may be used to develop benzofuran-based farnesyltransferase inhibitors as anti-cancer agents. It may also be used to prepare (20E)-N-[t-butyl-(S)-sulfinyl]-3β-(t-butyldimethylsilyloxy)-pregn-5-en-20-imine, an intermediate for the preparation of androgen receptor antagonists.

Uses

(S)-(-)-2-Methyl-2-propanesulfinamide is used in Suzuki reaction. It is also employed as a reagent for synthesizing chiral amines. It acts as a chiral auxiliary used in an asymmetric synthesis of trifluoroethylamines by conversion of trifluoroacetaldehyde to a chiral imine. It is also involved in the transformation of P,N-sulfinyl imine ligands through condensation with aldehydes and ketones, which can undergo iridium-catalyzed asymmetric hydrogenation of olefins. Further, it serves as a reagent for the preparation of chemicals and pharmaceutical intermediates.

60011-16-7
343338-28-3
Synthesis of (S)-(-)-2-Methyl-2-propanesulfinamide from (S)-tert-Butanethiosulfinate
Global( 455)Suppliers
Supplier Tel Email Country ProdList Advantage
Blocksynth Pharmaceutical Technology Co.,Ltd
0086-19817745290; +8619817745290 bd@blocksynth.com China 5657 58
WinWin Chemical CO., Limited
577-64498589 +8615325081899 sales@win-winchemical.com China 13849 58
Jiangsu shring Biopharma Co., Ltd.
+8613372282299 sales@shringchem.com China 3545 58
Changzhou uniringchem Co., Ltd.
+undefined13585446801 sales@uniringchem.com China 68 58
Hebei Yanxi Chemical Co., Ltd.
+8617531190177 peter@yan-xi.com China 5960 58
Shanghai UCHEM Inc.
+862156762820 +86-13564624040 sales@myuchem.com China 6506 58
Capot Chemical Co.,Ltd.
571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Shanghai Daken Advanced Materials Co.,Ltd
+86-371-66670886 info@dakenam.com China 14770 58
Beijing Cooperate Pharmaceutical Co.,Ltd
010-60279497 sales01@cooperate-pharm.com CHINA 1811 55
Hi-Tech Chemistry Corp
0519-86626038 yuhh@hitechem.com CHINA 811 58

Related articles

View Lastest Price from (S)-(-)-2-Methyl-2-propanesulfinamide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(S)-(-)-2-Methyl-2-propanesulfinamide pictures 2024-02-26 (S)-(-)-2-Methyl-2-propanesulfinamide
343338-28-3
US $0.00-0.00 / kg 1kg 98% Kgs BTC Nantong Pharmaceuticals Technology Co.,Ltd
(S)-(-)-2-Methyl-2-propanesulfinamide pictures 2024-02-23 (S)-(-)-2-Methyl-2-propanesulfinamide
343338-28-3
US $10.00-90.00 / g 5g 0.98 25kg Shanghai UCHEM Inc.
(S)-(-)-2-Methyl-2-propanesulfinamide pictures 2023-09-06 (S)-(-)-2-Methyl-2-propanesulfinamide
343338-28-3
US $0.00 / KG 1KG 99% 500000kg Hebei Guanlang Biotechnology Co., Ltd.
2-METHYL-2-PROPANE-SULFINAMIDE(S-ISOMER) (S)-tert-Butylsulfinamide, (>98.0% ee), 97+% (S)-(-)-2-METHYL-2-PROPANESULPHINAMIDE (S)-(-)-2-METHYL-PROPANE-2-SULFINIC ACID AMIDE (S)-(-)-TERT-BUTYLSULFINAMIDE (S)-(-)-TERT-BUTYL SULPHINAMIDE (S)-(-)-T-BUTYLMETHYLSULFINAMIDE (S)-(-)-2-Methylpropane-2-sulphinamide 98% [S(S)]-2-Methyl-2-propanesulfinaMide 2-PropanesulfinaMide, 2-Methyl-, [S(S)]- S-BSN S- tert butyl sulfenaMide (S)-tert-Butylsulfinamide (S)-(-)-2-Methyl-2-propanesulfinamide (S)-(?)-2-Methyl-2-propanesulfinamide solution ANTI-SBSN (N-TERM) antibody produced in rabbit Suprabasin (S)-(-)-tert-Butylsulfinamide (S)-(-)-2-Methyl-2-propanesulfinamide 97% Amino(tert-butyl)sulfaniumolate (S)-(-)-2-Methyl-2-propanesulfimide (S)-2-Methyl-2-propanesulfinamide,99%e.e. (S)-(-)-t-Butylmethylsulfinamide,min.97% (S)-(-)-tert-Butyl sulphinamide 98% (S)-(-)-t-Butyl sulfinamide, 98% ee (S)-TERT-BUTANESULFINAMIDE / (S)-(-)-2-METHYL-2-PROPANESULFINAMIDE (S)-(-)-2-METHYL-2-PROPANESULFINAMIDE,98.5+% (S)-TERT-BUTYLSULFINAMIDE,97+% (>98.0% EE) (S)-(-)-t-Butylmethylsulfinamide, min. 97% (S)-tert-Butylsulfinamide, (>98.0% ee) (S)-(-)-2-Methyl-2-propanesulfinamide (S)-(-)-t-Butylsulfinamide, min. 97% (S)-TERT-BUTANESULFINAMIDE / (S)-(-)-2-METHYL-2-P S-tert-butylsulfonamide (S)-Tert butane sulfonamide 98% (S)-(-)-2-Methyl-2-propanesulfinaMide(S)-(-)-2-Methyl-2-propanesulfinaMide finamide (S)-(-)-tert-Butylsulfinamide > (S)-(-)-tert-Butylsulfinamide, 98%, for synthesis (S)-(-)-2-Methyl-2-propanesulfinamide USP/EP/BP (S)-2-METHYLPROPANE-2-SULFINAMIDE (S)-(-)-T-BUTYLSULFINAMIDE TERT-BUTYL SULFINAMIDE Brilanestrant Impurity 10 343338-28-3 343338-27-8 3423338-28-3 343338-28-2 C3H11CNOS C4H9CH3SONH2 C4H11NOS Organic Building Blocks Sulfur-Based Sulfur Compounds Sulfonamides/Sulfinamides Building Blocks Asymmetric Synthesis Chiral Auxiliaries Asymmetric Synthesis