4-(4-BroMo-3-(1,3-dioxolan-2-yl)phenoxy)benzonitrile synthesis
- Product Name:4-(4-BroMo-3-(1,3-dioxolan-2-yl)phenoxy)benzonitrile
- CAS Number:1217366-74-9
- Molecular formula:C16H12BrNO3
- Molecular Weight:346.18
Yield:1217366-74-9 97.9%
Reaction Conditions:
with toluene-4-sulfonic acid in dichloromethane at 20 - 25;
Steps:
10 Example 10
At room temperature, 4-(4-bromo-3-formylphenoxy)benzonitrile (SM-1, 30.21 g, 0.10 mol), MED (13.94 g, 0.12 mol), p-toluenesulfonic acid (0.86 g, 0.005 mol) was added to dry dichloromethane (300ml), the temperature was controlled at 2025°C to the end of the reaction, saturated sodium bicarbonate solution (150ml) was added, the organic layer was separated and washed with purified water (150ml×3), saturated Washed with brine (150ml), dried over anhydrous sodium sulfate, filtered,The filtrate was concentrated under reduced pressure until no solvent flowed out to obtain 4-(4-bromo-3-(1,3-dioxolan-2-yl)phenoxy)benzonitrile with a yield of 97.9% and a purity of 99.87%.
References:
CN113801089,2021,A Location in patent:Paragraph 0056-0057
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