4-(4-Bromo-3-formyl-phenoxy)-benzonitrile synthesis
- Product Name:4-(4-Bromo-3-formyl-phenoxy)-benzonitrile
- CAS Number:906673-54-9
- Molecular formula:C14H8BrNO2
- Molecular Weight:302.12
1194-02-1
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Yield:906673-54-9 76%
Reaction Conditions:
with potassium carbonate in N,N-dimethyl-formamide at 100; for 10 h;
Steps:
1.1 Step 1 Synthesis of Compound 3
Compound 1 (2.0 g, 16.5 mmol), Compound 2 (3.3 g, 16.5 mmol) and potassium carbonate were sequentially placed.(3.4 g, 24.8 mmol) was added to a solution of DMF (20 ml), and the mixture was stirred at 100 ° C for about 10 h, and analyzed by spotting until the starting material was completely reacted.The reaction solution was cooled to room temperature.The reaction was quenched with water (15 mL)EtOAcThe organic phase was washed twice with saturated sodium chloride. The organic phase was collected, dried over anhydrous sodium sulfate and evaporated.The concentrate was subjected to column separation (eluent: petroleum ether/ethyl acetate (v/v) = 10:1),The white solid product was obtained in 3.8 g, yield 76%.
References:
CN109206446,2019,A Location in patent:Paragraph 0116; 0118; 0119; 0120; 0121
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