(3S,6R)-1-((benzyloxy)carbonyl)-6-methylpiperidine-3-carboxylic acid synthesis
- Product Name:(3S,6R)-1-((benzyloxy)carbonyl)-6-methylpiperidine-3-carboxylic acid
- CAS Number:1227916-29-1
- Molecular formula:C15H19NO4
- Molecular Weight:277.32
5470-70-2
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1227916-29-1
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Yield:-
Steps:
Multi-step reaction with 3 steps
1.1: hydrogenchloride; platinum(IV) oxide; hydrogen / methanol; water / 4.5 h / 20 °C / 3102.97 Torr
1.2: 15 - 25 °C
2.1: ChiralPak IC / carbon dioxide; isopropyl alcohol / Resolution of racemate; Supercritical conditions
3.1: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 1 h / 20 °C
3.2: pH Ca. 5
References:
Medina, Jesús R.;Becker, Christopher J.;Blackledge, Charles W.;Duquenne, Celine;Feng, Yanhong;Grant, Seth W.;Heerding, Dirk;Li, William H.;Miller, William H.;Romeril, Stuart P.;Scherzer, Daryl;Shu, Arthur;Bobko, Mark A.;Chadderton, Antony R.;Dumble, Melissa;Gardiner, Christine M.;Gilbert, Seth;Liu, Qi;Rabindran, Sridhar K.;Sudakin, Valery;Xiang, Hong;Brady, Pat G.;Campobasso, Nino;Ward, Paris;Axten, Jeffrey M. [Journal of Medicinal Chemistry,2011,vol. 54,# 6,p. 1871 - 1895]
1227916-30-4
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1227916-29-1
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501-53-1
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1227916-29-1
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