(1S,2R)-2-((1,3-dioxoisoindolin-2-yl)Methyl)-N,N-diethyl-1-phenylcyclopropanecarboxaMide synthesis
- Product Name:(1S,2R)-2-((1,3-dioxoisoindolin-2-yl)Methyl)-N,N-diethyl-1-phenylcyclopropanecarboxaMide
- CAS Number:1237261-65-2
- Molecular formula:C23H24N2O3
- Molecular Weight:376.45
1237261-60-7
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1074-82-4
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1237261-65-2
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Yield:1237261-65-2 85%
Reaction Conditions:
in dichloromethane; for 16 h;Reflux;Solvent;
Steps:
1.c c) Preparation of (1S,2R)-N,N-diethyl-2-phthalimidomethyl-1-phenylcyclopropylcarboxamide (Formula (II))
500 mL of a three-necked flask with mechanical agitation,Add the above(1S,2R)-N,N-diethyl-2-chloromethyl-1-phenylcyclopropylformamide dichloromethane and potassium phthalimide(40.75 g, 0.22 mol),And then refluxed for 16 hours, filtered and distilled at 50 ° C in dichloromethane (90 ml). Water (100 mL) was added and the distillation was continued. After drying without solvent, the residue was filtered to dryness to give pale yellow (1S,2R)-N,N-diethyl-2-phthalimidomethyl-1-phenylcyclopropylamide (63.95 g)Three-step total yield of 85% The purity was 98.5%.
References:
CN106083638,2016,A Location in patent:Paragraph 0065; 0070; 0071
172015-99-5
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1237261-65-2
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140-29-4
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1237261-65-2
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