ChemicalBook CAS DataBase List 1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone

1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone synthesis

8synthesis methods

Product Name:1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone
CAS Number:1267610-26-3
Molecular formula:C15H19N3O2
Molecular Weight:273.33

Add 25L of water and 25L of methanol to the 500L reactor, add 2.5kg of compound (I) and 250g of Raney cobalt under stirring, raise the temperature to 40-50 °C, slowly add 2.0kg of hydrazine hydrate (content 80%), keep warm 60-70 °C, reaction for 3h, the reaction was completed, filtered with diatomaceous earth, concentrated solvent was removed, and MTBE was added to the filter cake.2.20 kg of a white solid were obtained with a yield of 98% and a purity of 99.8%.

503615-03-0 Synthesis

3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one

503615-03-0
314 suppliers
$31.00/1g

1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone

1267610-26-3
229 suppliers
$40.00/5g

Yield:1267610-26-3 98%

Reaction Conditions:

with hydrazine hydrate in methanol;water at 40 - 70; for 3 h;Large scale;Solvent;Temperature;

Steps:

2; 3; 4; 5; 6 Example 5
Add 25L of water and 25L of methanol to the 500L reactor, add 2.5kg of compound (I) and 250g of Raney cobalt under stirring, raise the temperature to 40-50 °C, slowly add 2.0kg of hydrazine hydrate (content 80%), keep warm 60-70 °C, reaction for 3h, the reaction was completed, filtered with diatomaceous earth, concentrated solvent was removed, and MTBE was added to the filter cake.2.20 kg of a white solid were obtained with a yield of 98% and a purity of 99.8%.

References:

Shanghai Haoyuan Pharmaceutical Co., Ltd.;Zhao Jian;Chen Kuaikuai;Yang Chengwu;Li Shuoliang;Gao Qiang;Zheng Baofu CN108503580, 2018, A Location in patent:Paragraph 0042-0051

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1575-61-7 Synthesis