7-({2-[(1-Methyl-buta-1,3-dienyl)-phenyl-aMino]-pyriMidine-5-carbonyl}-aMino)-heptanoic acid Methyl ester synthesis
- Product Name:7-({2-[(1-Methyl-buta-1,3-dienyl)-phenyl-aMino]-pyriMidine-5-carbonyl}-aMino)-heptanoic acid Methyl ester
- CAS Number:1316216-07-5
- Molecular formula:C25H28N4O3
- Molecular Weight:432.51
Yield:1316216-07-5 54%
Reaction Conditions:
with N-ethyl-N,N-diisopropylamine;HATU in tetrahydrofuran at 20;
Steps:
1
A mixture of compound 4 (2.5 g, 8.58 mmol), aminoheptanoate 5 (2.52 g, 12.87 mmol), HATU (3.91 g, 10.30 mmol), DIPEA (4.43 g, 34.32 mmol) was stirred at rt overnight. After the reaction mixture was filtered, the filtrate was evaporated to dryness and the residue was purified by silica gel chromatography (petroleum ethers/EtOAc = 2/1) to give a brown solid(2 g, 54 %).
References:
WO2011/91213,2011,A2 Location in patent:Page/Page column 73; 75
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