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132714-93-3

Pyrrolo[1,2-a]pyrazine-1,4-dione, hexahydro-7-hydroxy-2-methyl-, (7R-cis)- (9CI) synthesis

3synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1: 95 percent / SOCl2 / 4 h / Ambient temperature
2: 87 percent / benzene / 2 h / Heating
3: 80 percent / methanol / 1) 60 deg C, 12 h, 2) room temperature, 8 h

References:

Diafi, Lahcen;Couquelet, Jacques;Tronche, Pierre;Gardette, Daniel;Gramain, Jean-Claude [Journal of Heterocyclic Chemistry,1990,vol. 27,# 7,p. 2181 - 2187]