ChemicalBook CAS DataBase List 2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidine-4,5,6-triamine

2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidine-4,5,6-triamine synthesis

12synthesis methods

Product Name:2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidine-4,5,6-triamine
CAS Number:1350653-30-3
Molecular formula:C17H14F2N8
Molecular Weight:368.34

1350653-29-0 Synthesis

2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-[(E)-phenyldiazenyl]pyrimidine-4,6-diamine

1350653-29-0
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2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidine-4,5,6-triamine

1350653-30-3
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Yield:1350653-30-3 100%

Reaction Conditions:

with hydrogen;10% Pd/C in N,N-dimethyl-formamide;

Steps:

11A.B

Variant B: Preparation starting from Example 1 OA:In DMF (800 ml), 39.23 g (85.75 mmol) of the compound from Example 10A were introduced and then 4 g of palladium (10% on carbon) were added. The mixture was hydrogenated with stirring overnight under standard hydrogen pressure. The batch was filtered over kieselguhr and the filter product was washed with a little DMF and then with a little methanol, and concentrated to dryness. The residue was admixed with ethyl acetate and stirred vigorously, and the precipitate was filtered off with suction, washed with ethyl acetate and diisopropyl ether and dried under a high vacuum over Sicapent.Yield: 31.7 g (100% of theory)LC-MS (Method 2): R_t+ = 0.81 minMS (ESIpos): m/z = 369 (M+H)

References:

WO2011/147810,2011,A1 Location in patent:Page/Page column 32