2-(1,1,1-trifluoro-2-Methylpropan-2-yl)-4H-pyran-4-one synthesis
- Product Name:2-(1,1,1-trifluoro-2-Methylpropan-2-yl)-4H-pyran-4-one
- CAS Number:1357476-64-2
- Molecular formula:C9H9F3O2
- Molecular Weight:206.16
1357476-62-0
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1357476-64-2
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Yield:1357476-64-2 395 g
Reaction Conditions:
with trifluoroacetic acid at 20; for 3 h;Cooling with ice;
Steps:
Step 3: Synthesis of compound D3-4
The reaction mixture in Step 2 was quenched with the addition of water (500 mL) in an ice bath, and then trifluoroacetic acid (50mL) was added, stirred at room temperature for 3h. When the reaction was completed, the reaction mixture was concentrated and extracted with EA.The organic layers were washed with brine, dried over anhydrous Na2SO4 and concentrated. The residue was purified by column chromatography (Hex/EA 100:1-10:1) to give brown solid. The brown solid was washed with a mixed solvent of HEX and EA (Volume ratio 50:1), the reaction mixture was filtered off with suction, the filtrate was collected and concentrated, to give compound D3-4 (395g). (0194) LC-MS [M+H] +: 207. (0195) 1H NMR (MeOD-d6): 1.59 (s, 6H), 6.39-6.41 (m, 1H), 6.53-6.54 (m, 1H), 8.12-8.14 (m, 1H).
References:
EP4056575,2022,A1 Location in patent:Paragraph 0189; 0193-0195
1163707-53-6
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1357476-64-2
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1163707-53-6
15 suppliers
$558.46/1gm:
1357476-64-2
19 suppliers
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