(2S)-2-(8-amino-1-bromoimidazo[1,5-a]pyrazin-3-yl)-1-Pyrrolidinecarboxylic acid phenylmethyl ester synthesis
- Product Name:(2S)-2-(8-amino-1-bromoimidazo[1,5-a]pyrazin-3-yl)-1-Pyrrolidinecarboxylic acid phenylmethyl ester
- CAS Number:1420478-88-1
- Molecular formula:C18H18BrN5O2
- Molecular Weight:416.27
![(S)-benzyl 2-(1-bromo-8-chloroimidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate](/CAS/20180703/GIF/1420478-87-0.gif)
1420478-87-0
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1420478-88-1
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Yield:1420478-88-1 87%
Reaction Conditions:
with ammonium hydroxide in isopropyl alcohol at 90; for 14 h;Sealed tube;
Steps:
1.5 Preparation of intermediate 6:
in a 250 mL sealed tube, intermediate 5 (6 g, 13.8 mmol), IPA (isopropanol) (90mL) and NH3·H2O (135 mL) were added successively. The reaction solution was reacted at 90 °C for 14 hours,concentrated and purified by reversed phase column to obtain intermediate 6 (5 g, yield: 87%) as a white solid.LCMS showed a molecular ion peak (M+1) 415.9.
References:
Hangzhou Sanyintai Pharmaceutical Technology Co., Ltd.;Yin, Jianming;YIN, Jianming;LV, Yubin;LI, Bangliang EP3480199, 2019, A1 Location in patent:Paragraph 0038
![(S)-benzyl 2-(8-chloroimidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate](/CAS/20180629/GIF/1418307-18-2.gif)
1418307-18-2
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1420478-88-1
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![1-Pyrrolidinecarboxylic acid, 2-[[[(3-chloro-2-pyrazinyl)methyl]amino]carbonyl]-, phenylmethyl ester, (2S)-](/CAS/20180703/GIF/1418307-17-1.gif)
1418307-17-1
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1420478-88-1
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55557-52-3
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$12.00/5g
1420478-88-1
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1148-11-4
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$6.00/10g
1420478-88-1
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