ChemicalBook CAS DataBase List ALPHA-AMINOISOBUTYRIC ACID METHYL ESTER HYDROCHLORIDE

ALPHA-AMINOISOBUTYRIC ACID METHYL ESTER HYDROCHLORIDE synthesis

7synthesis methods

Product Name:ALPHA-AMINOISOBUTYRIC ACID METHYL ESTER HYDROCHLORIDE
CAS Number:15028-41-8
Molecular formula:C5H12ClNO2
Molecular Weight:153.61

62-57-7
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$10.64/25G

ALPHA-AMINOISOBUTYRIC ACID METHYL ESTER HYDROCHLORIDE

15028-41-8
193 suppliers
$9.00/10g

Yield:-

Reaction Conditions:

with thionyl chloride in methanol;diethyl ether

Steps:

3.H 3-((2R)-2-((benzyloxy)amino)-3-(4-bromophenoxy)propyl)-5,5-dimethyl-2,4-imidazolidinedione
EXAMPLE 3H 3-((2R)-2-((benzyloxy)amino)-3-(4-bromophenoxy)propyl)-5,5-dimethyl-2,4-imidazolidinedione A solution of 2-aminoisobutyric acid (51.7 g) in methanol (500 mL) at 0° C. was treated with thionyl chloride (80.4 g) over 35 minutes, stirred for 30 minutes, warmed to room temperature, heated to 50° C. for 3 hours, cooled to room temperature, and concentrated. The concentrate was dissolved in methanol (200 mL), concentrated, dissolved in warm methanol (50 mL), treated with diethyl ether (300 mL), and filtered. The resulting solid was dried under vacuum (100 mm Hg) at 50° C. with a nitrogen bleed to provide 59.6 g of methyl 2-amino-2-methylpropanoate hydrochloride.

References:

Bailey, Anne E.;Hill, David R.;Hsiao, Chi-Nung W.;Kurukulasuriya, Ravi;Wittenberger, Steve;McDermott, Todd;McLaughlin, Maureen A. US2002/19539, 2002, A1

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67-56-1 Synthesis