
ALPHA-AMINOISOBUTYRIC ACID METHYL ESTER HYDROCHLORIDE synthesis
- Product Name:ALPHA-AMINOISOBUTYRIC ACID METHYL ESTER HYDROCHLORIDE
- CAS Number:15028-41-8
- Molecular formula:C5H12ClNO2
- Molecular Weight:153.61

62-57-7
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15028-41-8
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$9.00/10g
Yield:-
Reaction Conditions:
with thionyl chloride in methanol;diethyl ether
Steps:
3.H 3-((2R)-2-((benzyloxy)amino)-3-(4-bromophenoxy)propyl)-5,5-dimethyl-2,4-imidazolidinedione
EXAMPLE 3H 3-((2R)-2-((benzyloxy)amino)-3-(4-bromophenoxy)propyl)-5,5-dimethyl-2,4-imidazolidinedione A solution of 2-aminoisobutyric acid (51.7 g) in methanol (500 mL) at 0° C. was treated with thionyl chloride (80.4 g) over 35 minutes, stirred for 30 minutes, warmed to room temperature, heated to 50° C. for 3 hours, cooled to room temperature, and concentrated. The concentrate was dissolved in methanol (200 mL), concentrated, dissolved in warm methanol (50 mL), treated with diethyl ether (300 mL), and filtered. The resulting solid was dried under vacuum (100 mm Hg) at 50° C. with a nitrogen bleed to provide 59.6 g of methyl 2-amino-2-methylpropanoate hydrochloride.
References:
Bailey, Anne E.;Hill, David R.;Hsiao, Chi-Nung W.;Kurukulasuriya, Ravi;Wittenberger, Steve;McDermott, Todd;McLaughlin, Maureen A. US2002/19539, 2002, A1

67-56-1
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62-57-7
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$10.64/25G

15028-41-8
216 suppliers
$9.00/10g

84758-55-4
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$39.00/100mg

15028-41-8
216 suppliers
$9.00/10g

62-57-7
442 suppliers
$10.64/25G

74-88-4
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$15.00/10g

15028-41-8
216 suppliers
$9.00/10g