Welcome to chemicalbook!
Chinese English Japanese Germany Korea
400-158-6606
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List 17-Methyltestosterone

17-Methyltestosterone synthesis

10synthesis methods
Methyltestosterone, 17β-hydroxy-17α-methylandrost-4-en-3-one (29.1.7), is also synthesized from androstenolone by reacting it with methylmagnesiumiodide, forming the corresponding tertiary alcohol (29.1.6), and subsequent oxidation of the hydroxyl group at C3 to a ketone using chromium (VI) oxide. Simultaneous isomerization of the double bond takes place under the reaction conditions, giving the desired methyltestosterone (29.1.7).

-

Yield:-

Steps:

Multi-step reaction with 4 steps
1: hydroxylamine hydrochloride
2: pyridine; trichlorophosphate / N,N-dimethyl-formamide
3: sodium hydroxide; sodium tetrahydroborate
4: manganese(IV) oxide

References:

CN106397521,2017,A

17-Methyltestosterone Related Search: